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Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c by Robert M. Cohen, Robert S. Franco, Paramjit K. Khera,

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Presentation on theme: "Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c by Robert M. Cohen, Robert S. Franco, Paramjit K. Khera,"— Presentation transcript:

1 Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c by Robert M. Cohen, Robert S. Franco, Paramjit K. Khera, Eric P. Smith, Christopher J. Lindsell, Peter J. Ciraolo, Mary B. Palascak, and Clinton H. Joiner Blood Volume 112(10):4284-4291 November 15, 2008 ©2008 by American Society of Hematology

2 Scatter plot of TfR(+) reticulocyte HbA1c fraction and whole blood HbA1c fraction. Robert M. Cohen et al. Blood 2008;112:4284-4291 ©2008 by American Society of Hematology

3 The in vivo rate of formation of HbA1c. Robert M. Cohen et al. Blood 2008;112:4284-4291 ©2008 by American Society of Hematology

4 RBC disappearance in NDM and DM subjects. Robert M. Cohen et al. Blood 2008;112:4284-4291 ©2008 by American Society of Hematology

5 Time course of measured HbA1c fraction versus mean age of biotinylated RBCs. HbA1c fraction was measured in autologous biotinylated RBCs, sampled at various times (triangles) after reinfusion in 6 NDM (left) and 6 DM (right) human subjects. Robert M. Cohen et al. Blood 2008;112:4284-4291 ©2008 by American Society of Hematology

6 Relationship of Hb glycation rate to mean HbA1c fraction during the biotin label study. Robert M. Cohen et al. Blood 2008;112:4284-4291 ©2008 by American Society of Hematology

7 Impact of differences in mean RBC age on measured HbA1c. Robert M. Cohen et al. Blood 2008;112:4284-4291 ©2008 by American Society of Hematology


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