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Elastin Stabilizes an Infarct and Preserves Ventricular Function by Tomohiro Mizuno, Terrence M. Yau, Richard D. Weisel, Chris G. Kiani, and Ren- Ke Li.

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Presentation on theme: "Elastin Stabilizes an Infarct and Preserves Ventricular Function by Tomohiro Mizuno, Terrence M. Yau, Richard D. Weisel, Chris G. Kiani, and Ren- Ke Li."— Presentation transcript:

1 Elastin Stabilizes an Infarct and Preserves Ventricular Function by Tomohiro Mizuno, Terrence M. Yau, Richard D. Weisel, Chris G. Kiani, and Ren- Ke Li Circulation Volume 112(9 suppl):I-81-I-88 August 30, 2005 Copyright © American Heart Association, Inc. All rights reserved.

2 Figure 1. Left ventricular function, evaluated by echocardiography. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

3 Figure 2. Left ventricular function, evaluated in a Langendorff apparatus. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

4 Figure 3. The scar dimensions and left ventricular dimensions evaluated by echocardiography. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

5 Figure 4. The scar size (A) and left ventricular volumes (B) evaluated by planimetry. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

6 Figure 5. Evaluation of transgene expression of the recombinant elastin in vitro (A) and in vivo (B) by Western blotting. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

7 Figure 6. Staining of the transplanted endothelial cells and the recombinant elastin. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

8 Figure 7. Elastin deposition in the scar. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

9 Figure 8. Elastin deposition throughout the scar and border zone, 1 month after cell transplantation (elastic von-Giesson staining). Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

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