1. Torbjörn Turland European Product Manager BD PhaSeal TM PhaSeal Training 3 rd – 5 th December 2014 Oxford, UK Introduction to Patient Safety

2. Healthcare Worker Safety STAFF SAFETY PrescribingAdministration ManufacturingMonitoring Information Dispensing PATIENT SAFETY QUALITY = SAFETY

3. Do you think bacteria are killed by chemotherapy drugs? First question……

4.  Patients have an compromised immune system through: –Chemotherapy –Radiation  Much more need for sterile preparations than for e.g. TPN  Wrong perception that chemotherapy drugs would kill microorganism: –Depends on organism –Depends on product –No short term activity –Limited activity on long term Why Quality? It’s microbiology for the patient!

6. Microbiological challenge of four protective devices for the reconstitution of cytotoxic agents De Prijck, D’Haese, Vandenbroucke

7. PSEUDOMONAS AEROGINOSA  4 X 10 3 (= Real Case)  4 X 10 5 (= Worst Case) Contamination of Vial Drop

8.  Need to have a good decontamination protocol! Worst Case Scenario……

9. Contamination of Transfer Device with Pseud Aer

10. Results with multiple connections (n=10) Worst Case  PhaSeal

11.  You can protect the patient by using a device which limits the amount of contamination going into the vial  Spraying or swabbing alone was inadequate, as opposed to a combination of spraying [0.5% or 2.0% (w ⁄ v) chlorhexidine in isopropanol] and swabbing [70% (v ⁄ v) isopropanol].  Although PhaSeal afforded the lowest transfer of micro-organisms, adequate disinfection of the vial prior to connection remains required. Study Conclusions

12. Do you think bacteria are killed by chemotherapy drugs? First question……