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Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):425-437.

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Presentation on theme: "Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):425-437."— Presentation transcript:

1 Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):425-437. doi:10.7326/0003-4819-156-6-201203200-00005 Study flow diagram. 25-(OH)D = 25-hydroxyvitamin D; BMD = bone mineral density; BMI = body mass index; PCP = primary care physician. * Participants who discontinued the study who came in for the final visit. † Participants who were ineligible because of age criteria were included in the intention-to-treat analysis; there were no crossovers from assigned groups. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2 Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):425-437. doi:10.7326/0003-4819-156-6-201203200-00005 Vitamin D dose–response curve. Baseline, 6-mo, and final serum 25-(OH)D levels are presented according to dosage of vitamin D or placebo. A quadratic curve was the best fit for data. Levels of 25-(OH)D at 6 and 12 mo were significantly lower in the placebo group compared with all vitamin D dose groups individually (P < 0.05). 25-(OH)D = 25-hydroxyvitamin D. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3 Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):425-437. doi:10.7326/0003-4819-156-6-201203200-00005 Serum 25-(OH)D levels according to vitamin D dosage. Levels are shown with a fitted line by using the mixed-effects model, with 95% bootstrapped limits at 12 mo. 25-(OH)D = 25-hydroxyvitamin D. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4 Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):425-437. doi:10.7326/0003-4819-156-6-201203200-00005 Effect of BMI and vitamin D dose on levels of serum 25-(OH)D at 12 months. BMI <25 kg/m 2, n = 31; BMI 25.0–29.9 kg/m 2, n = 56; and BMI ≥30.0 kg/m 2, n = 76. 25-(OH)D = hydroxyvitamin D; BMI = body mass index. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5 Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):425-437. doi:10.7326/0003-4819-156-6-201203200-00005 Serum PTH levels, according to vitamin D dosage at 12 months. PTH = parathyroid hormone. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

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