1. Cardiovascular Health of Mothers and Offspring following Pregnancies Complicated with Preeclampsia (PET) Objectives We aimed to study the long-term sequelae of preeclampsia on the health of mothers and their offspring Background Women with a history of preeclampsia have been shown to have increased cardiovascular events and cardiovascular mortality. Little information exists on the health of offspring born to these mothers. Methods We recruited mothers and offspring from the Jerusalem Perinatal Study cohort 32 years after birth. Mothers were divided into two groups for comparison: mothers who had preeclampsia in the JPS cohort, and mothers without a history of preeclampsia. Offspring were divided into three groups: offspring born to preeclamptic pregnancies, offspring born to non-preeclamptic pregnancies whose mother had preeclampsia in another pregnancy, and offspring whose mothers had no preeclampsia. Participants were interviewed and examined for blood pressure and anthropometrics, and blood samples were drawn for serum lipids and glucose levels. P valuePETNo PET 0.03561.359.9Age (mean) <0.0017139Medically treated HTN (%) <0.00135.217.6Medically treated DM (%) 0.34945.9 40.5Hyperlipidemia (%) 0.0028.62.2Angina Pectoris (%) 0.04111.34.9History of stroke or MI (%) <0.001132122SBP (mmHg) 0.02982.279.4DBP (mmHg) 0.00198.893.6Mean BP (mmHg) 0.01499.495.0Waist (cm) 0.083113111Hip (cm) 0.04532.731.0BMI (Kg/m 2 ) 0.873102100Glucose (mg/dl) 0.053144127Triglycerides (mg/dl) 0.039194204Total-cholesterol (mg/dl) 0.103116123LDL (mg/dl) 0.02451.355.8HDL (mg/dl) P valuePET **PET sibling*No PET N=47N=33N=1391 0.48531.932.131.9Age (mean) 0.22646.863.648.7Male sex (%) 0.401333635263394Birthweight (gr) 0.0016.500.8Diabetes (%) 0.48703.81.6HTN (%) 0.0312.600Angina (%) 0.918000.2History of stroke or MI (%) <0.001113111 106SBP (mmHg) <0.00177.674.871.4DBP (mmHg) <0.00189.686.983.0Mean BP (mmHg) <0.00191.395.586.3Waist (cm) <0.001108110104Hip (cm) 0.03229.029.226.3BMI (Kg/m 2 ) *not exposed to PET in pregnancy, but mother has a history of PET in another pregnancy **exposed to PET in pregnancy Table 2 characteristics of offsprings, by history of preeclampsia Table 1 characteristics of mothers, by history of preeclamosia The association between preeclampsia and health of offspring and mothers in a 32 years of follow-up Conclusion Preeclampsia in the mother has late consequences not only for her own cardiovascular health but also for that of her offspring. Whether cardiovascular events are induced by preeclampsia per se or result from common pathways requires exploration Results Preeclampsia among mothers was associated with an increased prevalence of hypertension and diabetes mellitus. Compared with controls, mothers with a history of preeclampsia had higher BMI and waist circumference measurements, and increased blood pressure. Offspring of mothers with preeclampsia were at increased risk of diabetes and hypertension, as well as having higher BMI, SBP and DBP than controls. Compared with offspring to preeclamptic pregnancies, children born following normotensive pregnancies whose mothers had preeclampsia in another pregnancy had similarly increased BMI, but a lower prevalence of diabetes. ** *** ^ ORs adjusted for age and socioeconomic status, except for diabetes which is also adjusted for BMI # ORs adjusted for age, sex, and BMI. Siblings to PET were excluded from these analyses ** p value <0.01 *** p value < 0.001 Diabetes - defined as medically treated diabetes or glucose>200mg/dl. Hypertension - defined as medically treated hypertension or SBP>140mmHg or DBP>90mmHg Ronit Calderon-Margalit 1, Yechiel Friedlander 1, Orly Manor 1, Vardiella Meiner 2, Yael Sagi 1, Meytal Avgil Tsadok 1, Bella Savitsky 1, Ayala Burger 1, David Siscovick 3 and Ora Paltiel 1 1Braun School of Public Health and 2Department of Human Genetics, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel; 3 Departments of Epidemiology, University of Washington, Seattle, WA, USA. OR # OR ^ Offspring Mothers