1. Chapter 31 Essential Concepts in Molecular Pathology Companion site for Molecular Pathology Author: William B. Coleman and Gregory J. Tsongalis

2. Companion site for Molecular Pathology Copyright © 2009 by Academic Press. All rights reserved. 2 FIGURE 31.1 Venn diagram of pharmacogenomics showing the interactions of pharmacogenetics (PGx), pharmacokinetics (PK), and pharmacodynamics (PD), along with other environmental factors that affect drug response.

3. Companion site for Molecular Pathology Copyright © 2009 by Academic Press. All rights reserved. 3 FIGURE 32.2 Schematic diagram illustrating current medical practice and the changes that occur in a personalized medicine model.

4. Companion site for Molecular Pathology Copyright © 2009 by Academic Press. All rights reserved. 4 FIGURE 33.3 Allelic discrimination using real-time PCR and Taqman probes to identify individuals who are homozygous or heterozygous (circle) for a particular SNP.

5. Companion site for Molecular Pathology Copyright © 2009 by Academic Press. All rights reserved. 5 FIGURE 34.4 Schematic diagram of irinotecan metabolism.

6. Companion site for Molecular Pathology Copyright © 2009 by Academic Press. All rights reserved. 6 FIGURE 35.5 Immunohistochemical staining for the estrogen receptor in breast cancer.

7. Companion site for Molecular Pathology Copyright © 2009 by Academic Press. All rights reserved. 7 FIGURE 35.5 Simplified schematic diagram showing metabolism of tamoxifen by CYP450 enzymes with the resulting production of the active metabolite endoxifen.