1. Dial-a-Molecule Reagentless Transformations? ‘In 20-40 years, scientists will be able to deliver any desired molecule within a timeframe useful to the end user, using safe, economically viable and sustainable processes.’

2. Reagentless Transformations Relevant D-a-M Objectives: Low toxicity Low waste Reagentless Transformations: Photochemistry Thermochemistry Hyperbaric methods Electrochemistry Sonochemistry Rapid increase in relevant complexity Interaction with the end user

3. Reagentless Transformations Challenges Predictability – theory / mechanistic work (link to ‘Synthetic Route Design’) Lab of the future – better reactors, complete data collection To set-up ‘reagentless transformations’ or use their products may require steps mediated by reagents – link to ‘Catalytic Paradigms for 100% Efficient Synthesis’ Whole of Dial-a-Molecule needed!

4. Thermal Methods D. C. Harrowven et al. Angewandte Chem. Int. Ed. 2005, 44, 1221-1222.

5. Photochemical Methods

6. K. I. Booker-Milburn et al. J. Org. Chem. 2008, 73, 6497-6505.

7. Consortia Building Catalytic Asymmetric Photochemistry David Harrowven (Southampton) David Carberry (Bath) Andy Russell (Reading) Vibrational CD – Supporting Asymmetric Synthesis VCD - Adam Squires (Reading); Laurence Nafie (Syracuse & BioTools Inc.) Heterogeneous catalysis – Dave Watson (Surrey) Flow Chemistry – Steve Ley (Cambridge) Asymmetric Catalysis – Andre Cobb (Pharmacy – Reading); ATR (Reading)

8. Consortia Building ‘Click’ Chemistry and Reagentless Transformations Thermal Huisgen Reaction C. R. Bertozzi et al. J. Am. Chem. Soc. 2004, 126, 15046-15047 J. Moses et al. Org. Lett. 2009, 11, 1587