Presentation is loading. Please wait.

Presentation is loading. Please wait.

Modulation of NF ‐ κB ‐ dependent transcription and cell survival by the SIRT1 deacetylase by Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D.

Similar presentations


Presentation on theme: "Modulation of NF ‐ κB ‐ dependent transcription and cell survival by the SIRT1 deacetylase by Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D."— Presentation transcript:

1 Modulation of NF ‐ κB ‐ dependent transcription and cell survival by the SIRT1 deacetylase by Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, and Marty W Mayo EMBO J. Volume 23(12):2369-2380 June 16, 2004 ©2004 by European Molecular Biology Organization

2 NAD ‐ dependent HDACs regulate NF ‐ κB transcription. Fan Yeung et al. EMBO J. 2004;23:2369-2380 ©2004 by European Molecular Biology Organization

3 SIRT1 interacts with the RelA/p65 subunit of NF ‐ κB. Fan Yeung et al. EMBO J. 2004;23:2369-2380 ©2004 by European Molecular Biology Organization

4 Resveratrol inhibits the transactivation potential of the RelA/p65 protein. Fan Yeung et al. EMBO J. 2004;23:2369-2380 ©2004 by European Molecular Biology Organization

5 SIRT1 deacetylates lysine 310 on RelA/p65. Fan Yeung et al. EMBO J. 2004;23:2369-2380 ©2004 by European Molecular Biology Organization

6 Resveratrol and SIRT1 inhibit the RelA/p65 transactivation domain by targeting lysine 310. Fan Yeung et al. EMBO J. 2004;23:2369-2380 ©2004 by European Molecular Biology Organization

7 Resveratrol potentiates chromatin ‐ bound SIRT1 to inhibit cIAP ‐ 2 gene expression. Fan Yeung et al. EMBO J. 2004;23:2369-2380 ©2004 by European Molecular Biology Organization

8 Enhanced Sirtuin activity sensitizes cells to TNFα ‐ induced apoptosis. Fan Yeung et al. EMBO J. 2004;23:2369-2380 ©2004 by European Molecular Biology Organization

9 Differential SIRT1 ‐ mediated repression of p53 and NF ‐ κB controls, life and death signals. Fan Yeung et al. EMBO J. 2004;23:2369-2380 ©2004 by European Molecular Biology Organization


Download ppt "Modulation of NF ‐ κB ‐ dependent transcription and cell survival by the SIRT1 deacetylase by Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D."

Similar presentations


Ads by Google