1. Date of download: 7/6/2016 From: Renin–Angiotensin System Blockade Therapy After Surgical Aortic Valve Replacement for Severe Aortic Stenosis: A Cohort Study Ann Intern Med. 2014;161(10):699-710. doi:10.7326/M13-1505 Study flow diagram. ACE = angiotensin-converting enzyme; ARB = angiotensin-receptor blocker; AS = aortic stenosis; RAS = renin–angiotensin system; SAVR = surgical aortic valve replacement. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 7/6/2016 From: Renin–Angiotensin System Blockade Therapy After Surgical Aortic Valve Replacement for Severe Aortic Stenosis: A Cohort Study Ann Intern Med. 2014;161(10):699-710. doi:10.7326/M13-1505 Survival curves. Each symbol represents a death, and vertical bars represent 95% CIs estimated by Kaplan–Meier method. Solid lines are parametric estimates enclosed within a 95% confidence band. CABG = coronary artery bypass grafting; RAS = renin–angiotensin system; SAVR = surgical aortic valve replacement. Top. Unadjusted survival stratified by RAS blockade therapy. Middle. Survival in the propensity-matched groups stratified by RAS blockade therapy. Bottom. Survival in the propensity-matched groups stratified by RAS blockade therapy and CABG. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 7/6/2016 From: Renin–Angiotensin System Blockade Therapy After Surgical Aortic Valve Replacement for Severe Aortic Stenosis: A Cohort Study Ann Intern Med. 2014;161(10):699-710. doi:10.7326/M13-1505 Subgroup analysis of survival after SAVR with RAS blockade therapy. CABG = coronary artery bypass grafting; LVEF = left ventricular ejection fraction; RAS = renin–angiotensin system; SAVR = surgical aortic valve replacement. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 7/6/2016 From: Renin–Angiotensin System Blockade Therapy After Surgical Aortic Valve Replacement for Severe Aortic Stenosis: A Cohort Study Ann Intern Med. 2014;161(10):699-710. doi:10.7326/M13-1505 Temporal trends of echocardiographic changes in propensity-matched patients. Lines represent parametric estimates of temporal trend. Symbols represent raw data grouped by decile (without regard to repeated measurements) and plotted at mean time within the decile to provide a crude verification of model fit in RAS blockade and non–RAS blockade groups. LA = left atrial; LV = left ventricular; LVEF = left ventricular ejection fraction; RAS = renin–angiotensin system; SAVR = surgical aortic valve replacement. Top. Temporal trend of LV mass index after SAVR. Middle. Temporal trend of LVEF after SAVR. Bottom. Temporal trend of LA diameter after SAVR. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians