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Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657.

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Presentation on theme: "Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657."— Presentation transcript:

1 Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657. doi:10.7326/0003-4819-158-9-201305070-00004 Study flow diagram. LAS = lung allocation score; UNOS = United Network for Organ Sharing. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2 Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657. doi:10.7326/0003-4819-158-9-201305070-00004 Survival between LASΔ >5 and LASΔ ≤5 cohorts, by LAS-T strata. LAS = lung allocation score; LAS-T = LAS at transplantation. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3 Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657. doi:10.7326/0003-4819-158-9-201305070-00004 Adjusted survival between LASΔ >5 and LASΔ ≤5 for patients with obstructive disease and median value of all other regression coefficients, by LAS-T strata. Similar results were obtained for other native diseases. LAS = lung allocation score; LAS-T = LAS at transplantation. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4 Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657. doi:10.7326/0003-4819-158-9-201305070-00004 Estimate log(hazard ratio) for a change in LAS relative to a change of 0 when the change in LAS was considered as a continuous covariate with a restricted cubic spline transformation to allow for a nonlinear relationship. LAS = lung allocation score. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5 Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657. doi:10.7326/0003-4819-158-9-201305070-00004 Proportion of transplant recipients included in the study cohort with an acute change in LAS, by transplantation center. The centers are ordered by the mean number of transplantations performed in adults annually by center during the study period (May 2005 to December 2010), with the volume increasing from left to right. The horizontal line delineates the overall proportion of patients in the study cohort with an acute change in LAS before transplantation. LAS = lung allocation score. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6 Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657. doi:10.7326/0003-4819-158-9-201305070-00004 Log(hazard ratio) for the effect of an acute change by transplantation center, with 90% CIs when the effect of acute change was allowed to vary by center in a multivariable mixed-effect Cox model. The total volume of transplantations performed by center during the study period increases from left to right (only 64 centers had patients with acute change). Allowing the effect of acute change to vary by center was not significant (P = 0.34). The horizontal line delineates the overall proportion of patients in the study cohort with an acute change in LAS before transplantation. LAS = lung allocation score. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

7 Date of download: 7/2/2016 From: An Acute Change in Lung Allocation Score and Survival After Lung Transplantation: A Cohort Study Ann Intern Med. 2013;158(9):650-657. doi:10.7326/0003-4819-158-9-201305070-00004 Development of the wait-list study cohort. LAS = lung allocation score. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

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