2. Show & Tell Limsoon Wong Kent Ridge Digital Labs Singapore Role of Bioinformatics in the Genomic Era

3. Show & Tell What are the Themes of Bioinformatics? Bioinformatics = Data Mgmt + Knowledge Discovery Data Mgmt = Integration + Transformation + Cleansing Knowledge Discovery = Statistics + Algorithms + Databases

4. Show & Tell What are the Benefits of Bioinformatics?  To the patient:  Better drug, better treatment  To the pharma:  Save time, save cost, make more $  To the scientist:  Better science

5. Show & Tell Transcription Start Prediction

6. Show & Tell Transcription Start Prediction Results

7. Show & Tell Medical Record Analysis  Looking for patterns that are  valid  novel  useful  understandable

8. Show & Tell Medical Record Analysis Results  DeEPs, the “emerging pattern’’ method  Beats C4.5, CBA, LB, NB, TAN in 21 out of 32 UCI benchmarks  Works for gene expressions  ALL vs AML:  DeEPS (1 gene) - 0/38 & 3/34  Slonim (50 genes) - 2/38 & 5/34  Colon:  DeEPS (35 genes) - 4/62  Alon (1000 genes) - 6/62

9. Show & Tell Genome-Enabled Fruits  A lot of genes & proteins that are  candidate diagnosis indicators  candidate prognosis indicators  candidate drug targets What’s Next?

10. Show & Tell Evaluate & Choose the Better Candidates  Easier to access  Uncomplicated to modulate  Clear path to $  Has experience To do that, you will need to have ….

11. Show & Tell STRUCTURE EXPRESSION RELATED MOLECULES MUTATIONS DISEASES PATENTS INTERACTIONS A Molecular Connections Database consisting of...

12. Show & Tell Thank You