1. Date of download: 6/29/2016 From: Overdiagnosis of Invasive Breast Cancer Due to Mammography Screening: Results From the Norwegian Screening Program Ann Intern Med. 2012;156(7):491-499. doi:10.7326/0003-4819-156-7-201204030-00005 Figure 1. Implementation of the different groups in the breast cancer screening program in different regions from 1986 to 2005. The Appendix describes each of the 6 regions. Four groups are defined dependent on the county and the calendar year. The current screening group consists of women invited to screening. The current nonscreening group consists of women in areas where screening was not offered in the period that screening was offered. The historical groups consist of women residing in the different counties in the 10-y period before screening was offered. Data were obtained from Kalager et al (13). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 6/29/2016 From: Overdiagnosis of Invasive Breast Cancer Due to Mammography Screening: Results From the Norwegian Screening Program Ann Intern Med. 2012;156(7):491-499. doi:10.7326/0003-4819-156-7-201204030-00005 Figure 2. Yearly breast cancer incidence rates for women aged 50 to 79 y in the screening and nonscreening groups from 1986 to 2005. The researchers calculated the incidence rates of the current vs. historical nonscreening groups (the time effect). The incidence rate ratios of women aged 50–79 y in the program group include both changes in risk factors (the time effect), the increase in incidence due to lead time (lead-time effect), and the overdiagnosed cases. To account for lead time, we included women aged 70–79 y (older than the upper age limit of the screening program). We calculated overdiagnosis as the incidence rate ratios among women aged 50–79 y in the current vs. historical screening groups divided by the incidence rate ratios in the current vs. historical nonscreening groups. The peak in incidence observed in 1996–1997 is due to detection of prevalent cancer in the first screening round in region I (40% of the country). In theory, the increase in incidence due to lead time should be compensated for by a subsequent decrease in incidence among older age groups and may only be observed for age groups no longer offered screening (22). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 6/29/2016 From: Overdiagnosis of Invasive Breast Cancer Due to Mammography Screening: Results From the Norwegian Screening Program Ann Intern Med. 2012;156(7):491-499. doi:10.7326/0003-4819-156-7-201204030-00005 Figure 3. Age-specific invasive breast cancer incidence rates for the 4 groups. This figure shows the incidence rates for the current and historical screening groups (top), the incidence rates for the current and historical nonscreening groups (middle), and incidence rate ratios comparing the ratio of the incidence rate in the current and historical groups for both the screening and nonscreening groups (bottom). Only women aged 50–69 y in the current screening group were invited to undergo mammography screening. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 6/29/2016 From: Overdiagnosis of Invasive Breast Cancer Due to Mammography Screening: Results From the Norwegian Screening Program Ann Intern Med. 2012;156(7):491-499. doi:10.7326/0003-4819-156-7-201204030-00005 Appendix Figure 1. Defined daily doses for menopausal hormone therapy among all women in Norway from 1990 to 2010. Systemic treatment consisted of Anatomical Therapeutic Chemical group G03C-estrogens and G03F-combined estrogen and progesterone, and local treatment consisted of Anatomical Therapeutic Chemical group G03C. Adapted from the Norwegian Institute of Public Health. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 6/29/2016 From: Overdiagnosis of Invasive Breast Cancer Due to Mammography Screening: Results From the Norwegian Screening Program Ann Intern Med. 2012;156(7):491-499. doi:10.7326/0003-4819-156-7-201204030-00005 Appendix Figure 2. The defined daily doses for menopausal hormone therapy for women aged 60 to 69 y in the Norway counties from 2004 to 2010. Hormone therapy consisted of the Anatomical Therapeutic Chemical group G03C-estrogens and G03F-combined estrogen and progesterone. Data were obtained from the Norwegian Prescription Database. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 6/29/2016 From: Overdiagnosis of Invasive Breast Cancer Due to Mammography Screening: Results From the Norwegian Screening Program Ann Intern Med. 2012;156(7):491-499. doi:10.7326/0003-4819-156-7-201204030-00005 Appendix Figure 3. The defined daily doses for menopausal hormone therapy for women aged 50 to 59 y in the Norway counties from 2004 to 1010. Hormone therapy consisted of the Anatomical Therapeutic Chemical group G03C-estrogens and G03F-combined estrogen and progesterone. Data were obtained from the Norwegian Prescription Database. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

7. Date of download: 6/29/2016 From: Overdiagnosis of Invasive Breast Cancer Due to Mammography Screening: Results From the Norwegian Screening Program Ann Intern Med. 2012;156(7):491-499. doi:10.7326/0003-4819-156-7-201204030-00005 Appendix Figure 4. Yearly breast cancer incidence rates for women aged 50 to 69 y in the nonscreening groups and defined daily doses for menopausal hormone therapy for women of all ages in Norway from 1990 to 2005. Incidence rate is calculated from the data in the text, and data on hormone therapy are obtained from Appendix Figure 1. The incidence rate is smoothed by using a 3-y moving average. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

8. Date of download: 6/29/2016 From: Overdiagnosis of Invasive Breast Cancer Due to Mammography Screening: Results From the Norwegian Screening Program Ann Intern Med. 2012;156(7):491-499. doi:10.7326/0003-4819-156-7-201204030-00005 Appendix Figure 5. Rates of death from various causes among Norwegian women from 1951 to 2005. Rates are age-standardized to the Norwegian population of 1 January 1981. Death from breast cancer is also shown in a larger format (bottom). Data obtained from the Norwegian Institute of Public Health. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians