1. Date of download: 6/29/2016 From: Long-Term Health Outcomes in Women With Silicone Gel Breast Implants: A Systematic Review Ann Intern Med. 2016;164(3):164-175. doi:10.7326/M15-1169 Summary of evidence search and selection. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 6/29/2016 From: Long-Term Health Outcomes in Women With Silicone Gel Breast Implants: A Systematic Review Ann Intern Med. 2016;164(3):164-175. doi:10.7326/M15-1169 Forest plot for breast cancer: direct (within-study) comparisons. Random-effects model meta-analysis of ESs of incident breast cancer in women with breast implants compared directly with women without implants. Subgroup analyses were based on whether 100% of women in each study had silicone gel implants. See the Methods section for description of adequate and inadequate statistical adjustment. Adj = adjusted; ES = effect size; ND = no data; OR = odds ratio; P het = chi-square P value for heterogeneity; RR = risk ratio. * Adjusted only for age and year of implantation. † Adjusted for age, race, time since surgery, and “predictors of cancer.” ‡ Adjusted for “extraneous variables.” Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 6/29/2016 From: Long-Term Health Outcomes in Women With Silicone Gel Breast Implants: A Systematic Review Ann Intern Med. 2016;164(3):164-175. doi:10.7326/M15-1169 Forest plot of breast cancer: SIR analyses. Random-effects model meta-analysis of SIRs of incident breast cancer in women with breast implants indirectly compared with the general population. Studies explicitly or implicitly adjusted only for demographic variables, such as age and race. No studies of women all with silicone gel breast implants reported SIR analyses. ND = no data; P het = chi-square P value for heterogeneity; SIR = standardized incidence ratio. * Adjusted only for age and year of implantation. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 6/29/2016 From: Long-Term Health Outcomes in Women With Silicone Gel Breast Implants: A Systematic Review Ann Intern Med. 2016;164(3):164-175. doi:10.7326/M15-1169 Forest plot of rheumatoid arthritis. Random-effects model meta-analysis of ESs of incident rheumatoid arthritis in women with breast implants directly compared with women without implants. See the Methods section for description of adequate and inadequate statistical adjustment. Adj = adjusted; ES = effect size; HR = hazard ratio; ND = no data; OR = odds ratio; P het = chi-square P value for heterogeneity; RR = risk ratio. * Adjusted only for age and year of implantation. † Adjusted for age, body mass index, tobacco use, hormone replacement therapy, and history of breast cancer. ‡ Adjusted for age, race, time since surgery, calendar year, education, and family history. § Adjusted only for age and time since s urgery. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 6/29/2016 From: Long-Term Health Outcomes in Women With Silicone Gel Breast Implants: A Systematic Review Ann Intern Med. 2016;164(3):164-175. doi:10.7326/M15-1169 Forest plot of Sjögren syndrome. Random-effects model meta-analysis of ESs of incident Sjögren syndrome in women with breast implants directly compared with women without implants. See the Methods section for description of adequate and inadequate statistical adjustment. Adj = adjusted; ES = effect size; ND = no data; OR = odds ratio; P het = chi-square P value for heterogeneity; RR = risk ratio. * Adjusted only for age and year of implantation. † Adjusted for age, race, time since surgery, calendar year, education, and family history. ‡ Adjusted only for age and time since surgery. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 6/29/2016 From: Long-Term Health Outcomes in Women With Silicone Gel Breast Implants: A Systematic Review Ann Intern Med. 2016;164(3):164-175. doi:10.7326/M15-1169 Forest plot of Raynaud syndrome. Random-effects model meta-analysis of ESs of incident Raynaud syndrome in women with breast implants directly compared with women without implants. See the Methods section for description of adequate and inadequate statistical adjustment. Adj = adjusted; ES = effect size; ND = no data; OR = odds ratio; P het = chi-square P value for heterogeneity; RR = risk ratio. * Adjusted only for age and year of implantation. † Adjusted only for age. ‡ Adjusted for age, connective tissue disease history, depression, tobacco use, alcohol use, body mass index, parity, and age at first birth. § Adjusted for age, race, time since surgery, calendar year, education, and family history. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians