1. Diuretics and dehydrant drugs 基础医学各论 II

2. The Kidney: Excretion water, ions, and toxic metabolitesExcretion water, ions, and toxic metabolites

3. BA Renal structures for urine generation (A) and osmotic gradient (B)

4. Na +, Cl － reabsorption in the kidney 25 ％ Na + 65-70 ％ Na + 10 ％ Na +

5. Reabsorption sites of Na +, K +, Cl -, and other ions

7. A. Diuretic drugs A diuretic is any substance influence the rates of transport of Na +, K +, Cl - ， HCO 3 - and urate, increases urine and solute excretion.

8. Classification of diuretic drugs Loop diuretics- §high efficacy §furosemide 呋塞米 §thick ascending limb of Henle loop §inhibiting Na + -K + -2Cl - symport Thiazide diuretics §moderate efficacy §hydrochlorothiazide 氢氯噻嗪 §distal convoluted tubule §inhibiting Na + -Cl - symport K + -sparing diuretics §low efficacy §spironolactone 螺内酯 §late distal tubule and collecting duct §inhibiting renal epithelial Na + channels A. Diuretic drugs

10. Furosemide呋塞米 Bumetanide布美他尼 Etacrynic acid 依他尼酸 A. Diuretic drugs Loop diuretics

11. Furosemide 速尿 1. Pharmacological effects (1) Diuretic effects §Inhibiting the Na + -K + -2Cl - cotransporter （ symport) of the luminal membrane in the thick portion of the ascending limb of the loop of Henle, and reducing the reabsorption of Na +, K + and Cl -. §Most efficacious among the diuretic drugs, because the ascending limb accounts for the reabsorption of 25-30% of filtered NaCl and downstream sies are not able to compensate for this increased Na + load. A. Diuretic drugs

13. §Blocking kidney’s ability to concentrate urine during hydropenia, by decreasing the hypertonic medullary interstitium. §Impairing kidney’s ability to excrete a dilute urine. §Also, increasing excretion of Ca 2+, Mg 2+ by abolition of transepithelial potential difference. A. Diuretic drugs

14. loop diuretics urine concentration urine dilute

15. (2) Vasodilatation §Renal vasodilatation: renal blood flow  §Dilating veins: cardiac preload  A. Diuretic drugs

16. 2. Clinical uses (1) Severe edema: ineffective by thiazides (2) Acute pulmonary edema: heart failure (3) Acute renal failure: combined with dopamine (4) Hypercalcemia (5) Detoxication of toxins or drug overdose A. Diuretic drugs

17. 3. Adverse effects (1) Imbalance of water and electrolytes: acute hypovolumia; hypokalemia; etc. acute hypovolumia; hypokalemia; etc. (2) Ototoxicity: hearing damage, contraindicated to combine with aminoglycoside antibiotics (3) Other effects: GI reactions, hyperuricemia ( 尿酸增高 ), arrhythmias, RAAS activity , etc. A. Diuretic drugs

18. Other loop diuretic drugs §Bumetanide 布美他尼： similar to furosemide, but less adverse effects §Torasemide 托拉塞米： stronger and longer actions §Etacrynic acid 依他尼酸： weaker actions and more severe adverse effects A. Diuretic drugs

19. 苄氟噻嗪氯噻嗪氢氯噻嗪氢氟噻嗪甲氯噻嗪泊利噻嗪三氯噻嗪 Thiazide diuretic drugs A. Diuretic drugs

20. Thiazide diuretic drugs 1. Pharmacological effects and clinical uses (1) Diuretic effects Acting on distal convoluted tubule, inhibiting Na + -Cl - cotransporter (symport) Decreasing kidney’s ability to dilute urine Increasing the excretion of Na +, Cl -, K +, Mg 2+, HCO 3 -, but increasing the reabsorption of Ca 2+ in distal convoluted tubule A. Diuretic drugs

22. thiazides urine dilute

23. §Used in treatment of mild and moderate edema in cardiac and renal diseases, and hepatic diseases with cautions; §Used in treatment of hypercalciuria and calcium oxalate stones in urinary tract. (2) Antihypertensive effects § blood volume  § spasm responsiveness of arterial smooth muscles  A. Diuretic drugs

24. (3) Diabetes insipidus ( 尿崩症） §Unique ability to produce a hyperosmolar urine, and can substitute for the antidiuretic hormone in the treatment of nephrogenic diabetes insipidus. §The urine volume of such individuals may drop from 11 L/day to 3 L/day when treated with the drug. A. Diuretic drugs

25. 2. Adverse effects (1) Imbalance of eletrolytes hypokalemia hypomagnesemia hyponatremia hypochloremia cautions: dose individualization, K + supplement (2) Dysfunctio of metabolism hyperglycemia hyperlipidemia hyperuricemia contraindicated in diabetes and gout patients (3) Hypersensitivity bone marrow supression, dermatitis, necrotizing vasculitis, interstitial nephritis, etc. A. Diuretic drugs

26. Potassium-sparing diuretics Spironolactone 螺内酯 Spironolactone 螺内酯 Triamterene 氨苯喋啶 Triamterene 氨苯喋啶 Amiloride 阿米洛利 Amiloride 阿米洛利 A. Diuretic drugs

27. Spironolactone 螺内酯 SpironolactoneAldosterone A. Diuretic drugs

28. Spironolactone 螺内酯 1. Pharmacological effects Blocking aldosterone receptor Decreasing Na + reabsorption and K + excretion Weaker, slow acting, and lasting duration A. Diuretic drugs

29. Action of spironolactone: Blocking the effects of aldosterone

30. spironolactone

31. 2. Clinical uses §Edema with increased aldosterone levles §Combined with other diuretic drugs 3. Adverse effects (1) Hyperkalemia (2) Sex hormone-like effects (3) GI reactions (4) CNS reactions A. Diuretic drugs

32. triamterene triamterene amiloride amiloride A. Diuretic drugs Triamterene 氨苯喋啶 Amiloride 阿米洛利

33. 1. Pharmacological effects §Blocking renal epithelial Na + channels: decreasing Na + -K + exchange 2. Clinical uses §Similar to spironolactone 3. Adverse effects §Hyperkalemia, GI reactions, etc. A. Diuretic drugs

35. B. Dehydrant agents Mannitol 甘露醇 OH OH OH OH OH OH OH OH OH OH OH OH Osmotic diuretics

36. 1. Pharmacological effects (1) Dehydrant effects (2) Diuretic effects (osmotic diuretic effects) 2. Clinical uses (1) Brain edema (2) Glaucoma (3) Acute renal failure: prevention and early treatment B. Dehydrant agents

37. 3. Adverse effects (1) Elevated extracellular osmolality: pulmonary edema, etc. (2) Hyponatremia and dehydration: headache, nausea, vomiting, etc. Contraindicated in anuric due to severe renal diseases, active cranial bleeding, heart failure Contraindicated in anuric due to severe renal diseases, active cranial bleeding, heart failure B. Dehydrant agents

38. Other dehydrant drugs §Sorbitol 山梨醇 §Hypertonic glucose (50%) 高渗葡萄糖 §Urea 尿素 §Glycerin 甘油 §Isosorbide 异山梨醇 B. Dehydrant agents