1. Prader-Willi Syndrome
Kalena Spinola

2. Description
A cogential (present from birth) disease, affecting many parts of the body. People with this condition are often obese, have reduced muscle tone, mental ability, and produce little or no sex hormones.

3. Symptoms Physical Almond Shaped Eyes Short Stature Small Hands & Feet
Behavior Problems
Obsessive/Compulsive
Actions
Depression
Quick Temper

4. Symptoms Infants-Childhood Weak Muscle Tone Trouble Eating
Sleep Abnormalities
Body Temperature
Delayed Motor Development
Mental Retardation

5. Symptoms Adolescence-Adulthood Delayed Puberty Obesity Food Cravings
Leads to:
Diabetes
High Blood Pressure
Joint/Lung Problems

6. Effecting Traits Population Affects 1 in 10,000-25,000 births
Occurs in all Races
Effects Male & Female
Affects 1 in 10,000-25,000 births
Life Expectancy Normal

7. Inheritance Chromosome 15 Deletion Alterations Locus: 15q11-q13
Chromosome Partial Deletion
Deletion of Entire Chromosome
Maternal Disomy
Imprinting Defect Chromosome

8. Reproduction Spontaneous genetic disorder Random occurance
Reproduction is normal

9. Causes Normal Development Depends on Chromosome 15
Effects Hypothalamus Region
registers feelings of hunger
Lack of muscle mass
Fewer calories burned-Obesity

10. Treatments/Cures No Whole Cure Various Therapies
Physical, Speech, Occupational, etc
Special Feeding TEchniques
Strict Diet/Weight Control

11. Additional Information
Most common genetic cause of obesity
Can be detected before birth
PWS-like disorder can be developed

12. Resources