1. Generation Scotland Cognitive Expert Working Group Ian Deary & Riccardo Marioni et al.

2. Overview Personality traits – neuroticism – extraversion GHQ-28: mood Cognitive ability – memory – processing speed – executive function – vocabulary Core Team

3. Cognitive ability by age in GS:SFHS

4. GS 10 years ago today, almost

5. Key papers (led by cognitive EWG) GWAS – Educational Attainment (Nature, 2016) – Cognitive ability (Mol Psychiatry, 2015 & 2016) – Neuroticism (JAMA Psych, 2015 & Mol Psychiatry, 2016) – Extraversion (Behavior Genetics, 2016) Other – Runs of homozygosity and intelligence (Nature, 2015) – Education genes as IQ proxies (PNAS, 2014) – Gene networks for IQ (Nature Neuroscience, 2016)

6. Davies et al. (2015) Mol Psychiat, 20, 183.

7. General Cognitive Ability

8. Davies et al. (in press) Mol Psychiat.

9. Davies et al. (in press) Mol Psychiat. UK Biobank Cognitive Ability GWAS: PGRS checks Generation Scotland LBC1936

10. Smith et al. (in press) Mol Psychiat.

11. UK Biobank/GS Neuroticism GWAS Meta-analysis

12. Johnson et al. (2016, Nat Neurosci, Feb).

13. Werling & Saunders (2016, Nat Neurosci, Feb) explain the Johnson paper better than we do.

15. Werling & Saunders (2016, Nat Neurosci, Feb) News and Views on the Johnson et al paper.

16. Johnson et al. (2016, Nat Neurosci, Feb).

17. Additional papers (all EWG-led) Polygenic prediction – Body Mass Index and IQ (Mol Psychiatry, 2016) – Stroke and IQ (Neurology, 2016) – Coronary Artery Disease (Int J Epidemiology, 2016) APOE papers – Associations with IQ (Eur J Human Genetics, 2015) – Interaction with IQ, depression (Psychosom Med, 2015) Exome Sequencing – IQ (Twin Res Hum Genet, 2015)

18. Shared genetic influences for Education, IQ, and SES EducationIntelligenceSES Education0.39 (SE 0.01)0.22 (SE 0.01) Intelligence0.95 (SE 0.13)0.25 (SE 0.01) SES0.45 (SE 0.18)0.26 (SE 0.16) Genetic correlations – do the same genes influence the traits? Phenotypic correlations – do those with more education score highly on intelligence tests and live in less deprived areas? Published in Intelligence (2014)

19. Acknowledgements Carmen Amador Archie Campbell Gail Davies Ian Deary Saskia Hagenaars Sarah Harris Caroline Hayward David Hill Shona Kerr Michelle Luciano Riccardo Marioni Reka Nagy David Porteous Stuart Ritchie Peter Visscher