1. 陳京瑜

2.  Inflammatory  Infectious  Hereditary  Acquired metabolic and toxic  Traumatic  Tumor

3.  Guillain - Barre syndrome ◦ Autoimmune disease following a virus infection ◦ Muscle weakness, paralysis bilaterally ◦ Ascending paralysis ◦ Tingling, clumsiness ◦ Breathing assistance ◦ Get worse very quickly. Only a few hours to reach the most severe symptoms.

4.  Chronic inflammatory demyelinating polyradiculoneuropathy ◦ Chronic or subacute course, usu. relapse ◦ Mixed sensorimotor polyneuropathy ◦ Reflexes are usually absent ◦ high levels CSF total protein

5.  Direct infection of Schwann cells in leprosy  Chickenpox, VZ virus ◦ Sensory ganglia in brain or spinal spinal cord

6.  Hereditary Motor and Sensory Neuropathy Type I  AD with multigenetic forms  The nerves in the legs are affected first and most severely ◦ Foot drop (inability to hold foot horizontal) ◦ Foot deformity (very high arch to feet) ◦ Loss of lower leg muscle, which leads to skinny calves ◦ Numbness in the foot or leg ◦ "Slapping" gait (feet hit the floor hard when walking) ◦ Weakness of the hips, legs, or feet

7.  Peripheral neuropathy in adult-onset DM  Metabolic and nutritional peripheral neuropathy ◦ Renal failure, chronic liver disease, chronic respiratory insufficiency, hypothyroidism ◦ Vitamin B12, B6, E  Neuropathy associated with malignancy

8.  Laceration  Avulsion ◦ Force applied to limb  Traumatic neuroma  Compression neuropathy

9.  Myasthenia Gravis ◦ Antibody to AchR ◦ Easily fatigue ◦ Cranial muscle involved early --- ptosis ◦ Limb weakness proximal  Lambert-Eaton Myasthenic Syndrome ◦ Antibody to presynaptic voltage-gated calcium channel