1. Singlet oxygen: From discovery to natural and biologically active product synthesis November, 8-15-22-28 th 2005 By Isabelle Bonnaventure Literature Meeting

2. Presentation Outlook

3. Discovery of 1 O 2 and use as a reagent

4. Properties of 1 O 2

5. Generation of 1 O 2

7. Reaction Overview

8. Ene reaction: Introduction

10. Ene reaction: Mechanism

13. Ene reaction: “cis effect”

15. Ene reaction: “cis effect” in styrene derivatives

16. Ene reaction: large group non-bonded effect

17. Ene reaction: bulky subtituents

18. Ene reaction: gem dimethyl/diethyl trisubstituted olefins

19. Ene reaction: hydroxyl group directing effect

23. Ene reaction: EWG at vinylic and allylic position

24. Ene reaction: cyclic molecules

27. Ene reaction: diastereoselectivity?

34. Comparison with other  -oxidation methods

35. [4+2] cycloaddition

36. [2+2] cycloaddition

37. [4+2], [2+2] cycloaddition or ene reaction ?

42. Ene reaction: application

44. [4+2] cycloaddition: application

46. [2+2] cycloaddition: application

48. Conclusion