1. SCHMIDT REACTION

2. CONTENTS:
INTRODUCTION
MECHANISM
APPLICATIONS

3. INTRODUCTION: Rearrangement reaction is also called Molecular
It is a type of Named Rearrangement reaction.
Rearrangement reaction is also called Molecular
Rearrangement.
This rearrangement involves migration of an
alkyl or aryl group with its bonding electrons
from carbon to the adjacent nitrogen atom.

4. DEFINITION: Carboxylic acids and hydrazoic acids react in presence of concentrated sulphuric acids to give amines.
Schmidt reaction also occur in ketones

5. FOR ALDEHYDES:
This reaction closely releated to Hofmann and Curtius reaction, of all which involves formation of isocyanate intermediate through the migration of group from carbon to nitrogen.
the rearrangement closely resemble the Beckmann rearrangement.

6. MECHANISM FOR ACIDS:

7. FOR STERICALLY HINDERED ACIDS:
EXAMPLE 2,4,6 TRI METHYL BENZOIC ACIDS
2,4,6 Trimethyl benzoic acid

8. REACTION WITH KETONES:

9. MECHANISM FOR ALDEHYDES:

10. IF ‘H’ MOVES:

11. APPLICATIONS: Example 1:
PREPARATION OF PRIMARY AMINES:
Example 1:
It is a direct method for the preparation of primary amines from carboxylic acid and give usually better yield
than the hofmann or curtius reaction.

12. Example 2:

13. PREPARATION OF a AMINOACIDS:

14. Preparation of lactones:
Cyclic ketones react to give lactones

15. If excess of hydrazoic acid used:
cyclic ketones tetrazoles

16. THANK YOU