1. Liquid Medication Delivery System Engineering World Health Amanda Feest – Team Leader Val Maharaj – BSAC Nate Cira – Communicator Brian Mogen – BWIG Prof. Thompson – Advisor Prof. Webster – UW contact Prof. Malkin – EWH contact

2. Outline Problem Statement Background Product Design Specifications Design Alternatives Decision Matrix Future work

3. Problem Statement Seal donated medication bottles Measure the proper dosage Dispense medication Must be inexpensive

4. Background Current Donation Program Goal: To effectively distribute donated medication Viramune® (NNRTI) donated by Boehringer Ingelheim Reduces mother-to-child transmission by 50% 3 2

5. Background Current dispensing method Method Syringe inserted into bottle Dose drawn up Syringe capped, put in foil pouch Problems Expensive Can spill while dispensing Open to air (spoilage/contamination) Must have multiple parts present

6. Product Design Specifications Must dispense at least 4000 doses Must be produced in quantities of 2000 Must be manufactured for $2/device Goal of 50¢/device Must dispense.6mL ±.05mL Materials must not react with medication

7. Advantages Cheap Easy to manufacture Low maintenance Disadvantages Low accuracy May not be applicable for all bottle types Positive Pressure Device

8. “Liquid Pour” Spout Advantages Very easy to use Can be formatted for all bottle types Disadvantages Expensive Hard to manufacture Low accuracy One dose always exposed 4

9. Stopper and Syringe Sealed with a stopper Tubing attaches components Syringe withdraws and expels dosage 7 6 8 5

10. T Valve Rotating T valve Champagne rubber stopper Syringe Tubing 9

11. One Way Valves T junction One way valves Champagne rubber stopper Syringe Tubing

12. Valve Types Ball check valve Binder Clip 1011

13. Perforated Tube Perforated tube Champagne rubber stopper Syringe One way valve

14. Positive pressure device Liquid Pour Spout Syringe and tubing Ability to meet cost target (20%) 141218 Accuracy of dose (20%) 12 18 Sterility (20%)10616 Ease of manufacture (10%) 7310 Ease of assembly (10%) 7107 Ease of use (10%)10 8 Durability (10%)1098 Total706285 Design Matrix

15. Future Work Submit design to EWH Order supplies Build prototype Test prototype Enter the EWH competition

16. References 1. www.aidsaction.org/legislation/pdf/mom2child.pdf www.aidsaction.org/legislation/pdf/mom2child.pdf 2. www.usip.org/pubs/images/hiv-aids_africa.gif www.usip.org/pubs/images/hiv-aids_africa.gif 3. http://www.msf.org/source/countries/africa/lesotho/2006/project/hut&country side.jpg http://www.msf.org/source/countries/africa/lesotho/2006/project/hut&country side.jpg 4. http://precisionpours.com/pages/pours3.html http://precisionpours.com/pages/pours3.html 5. http://shschem.pbwiki.com/f/rubber%20stopper.jpg http://shschem.pbwiki.com/f/rubber%20stopper.jpg 6. http://www.pastemagazine.com/blogs/images/uploads/2007/02/champagne _cork.jpg http://www.pastemagazine.com/blogs/images/uploads/2007/02/champagne _cork.jpg 7. http://www.drillspot.com/pimages/418/41854_300.jpg http://www.drillspot.com/pimages/418/41854_300.jpg 8. http://www.omiltd.com/new%20images/carina/band%20deep%20etch.jpg http://www.omiltd.com/new%20images/carina/band%20deep%20etch.jpg 9. http://www.vetquip.com.au/products/3%20way%20stopcock.jpg http://www.vetquip.com.au/products/3%20way%20stopcock.jpg 10. http://qpmstationery.com/Images/Products/BindersClipN00004.jpg http://qpmstationery.com/Images/Products/BindersClipN00004.jpg 11. http://www.maritime.org/fleetsub/hydr/img/fig1-19.jpg http://www.maritime.org/fleetsub/hydr/img/fig1-19.jpg