1. 1 Centchroman ® Key Features of a Nonhormonal Contraceptive Pill

2. 2 What is Centchroman A new once-a-week non-hormonal oral contraceptive that: $Is safe, easy-to-use and highly effective (1.63 pregnancies per 100 woman years) $Is free of the side effects common to combined oral contraceptive pills Source: Roy et al 1976.

3. 3 How Does Centchroman Work !Potent anti-estrogen, weak estrogen !When given daily, induces ovulation (FSH/LH increase) !When given once-a-week, no change in FSH/LH In Humans Source: Roy et al 1976.

4. 4 How Does Centchroman Work continued !Contraceptive effect due to: $Slight increase in zygote transport $Accelerated blastocyst formation $Suppression of endometrial maturation !Net effect: Implantation prevented In Humans Source: Singh et al 1986.

5. 5 Effectiveness of Centchroman !Phase III clinical trial: 10 centers !Schedule: weekly !Dose of Centchroman:30 mg !Number of women: 898 !Duration of use: 13,483 months !Pregnancy rate (Pearl Index): 2.84 Study Design Source: Puri et al 1988.

6. 6 Effectiveness of Centchroman !Phase III clinical trial: 7 centers !Schedule: Twice weekly !Dose: 30 mg twice weekly (3 months) 30 mg weekly thereafter !Number of women: 377 !Duration of use: 3,932 months !Pregnancy rate (PI): 1.83  Cumulative pregnancy 1.63 " 0.74 rate at 12 months: Study Design Source: Nityanand S et al 1991.

7. 7 Adverse Effect of Centchroman Source: Centchroman 1991; Puri et al 1988.

8. 8 Centchroman: Return of Fertility N=37 Source: Centchroman 1991.

9. 9 Centchroman Based on limited studies, Centchroman: $is a highly effective, safe and easy-to-use once-a- week oral contraceptive $is free of side effects except delayed menses (6–8 %) $does not delay return of fertility (97 % pregnant by 12– 24 months) $has no adverse effects on endocrine, hematologic, liver and lipid metabolism $does not cause congenital abnormalities in infants born because of user failure Summary

10. 10 Centchroman: Centron Package