1. Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Clopidogrel Pretreatment Before Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction Treated With Fibrinolytics: The PCI-CLARITY Study JAMA. 2005;294(10):1224-1232. doi:10.1001/jama.294.10.1224 CABG indicates coronary artery bypass grafting; PCI, percutaneous coronaryintervention. Figure Legend:

2. Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Clopidogrel Pretreatment Before Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction Treated With Fibrinolytics: The PCI-CLARITY Study JAMA. 2005;294(10):1224-1232. doi:10.1001/jama.294.10.1224 P values are derived from a Cox proportionalhazards model as described in the “Methods.” Figure Legend:

3. Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Clopidogrel Pretreatment Before Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction Treated With Fibrinolytics: The PCI-CLARITY Study JAMA. 2005;294(10):1224-1232. doi:10.1001/jama.294.10.1224 Subgroup analyses are based on available data for each characteristic.The overall treatment effect is represented by the diamond, the left and rightborders of which indicate the 95% confidence interval (CI). The vertical dashedline represents the overall treatment effect. The squares indicate the adjustedORs and the size of each square is proportional to the number of patientsin the individual analysis. All interaction P valueswere nonsignificant. Gp indicates glycoprotein; LMWH, low-molecular-weightheparin; UFH, unfractionated heparin. Figure Legend:

4. Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Clopidogrel Pretreatment Before Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction Treated With Fibrinolytics: The PCI-CLARITY Study JAMA. 2005;294(10):1224-1232. doi:10.1001/jama.294.10.1224 Individual trial and combined results for the effect of clopidogrelpretreatment on myocardial infarction before PCI (panel A) or cardiovasculardeath or myocardial infarction after PCI up to 30 days (panel B). The squaresindicate the unadjusted odds ratios (ORs) and the size of each square reflectsthe statistical weight of a trial in calculating the OR; the horizontal linesindicate the 95% confidence intervals (CIs). Tests for heterogeneity: χ21 = 0.11, P =.74(panel A); χ22= 1.37, P =.51 (panel B). CREDO indicates Clopidogrel for the Reductionof Events During Observation; PCI-CLARITY, PCI-Clopidogrel as Adjunctive ReperfusionTherapy; PCI- CURE, PCI-Clopidogrel in Unstable angina to prevent RecurrentEvents. Ellipses indicate not applicable. Figure Legend: