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1 – 3D atlases of normal craniofacial development (Mouse and Avian) 2 – 3D atlases that define the phenotypes of mutant, transgenic and morpholino-based.

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Presentation on theme: "1 – 3D atlases of normal craniofacial development (Mouse and Avian) 2 – 3D atlases that define the phenotypes of mutant, transgenic and morpholino-based."— Presentation transcript:

1 1 – 3D atlases of normal craniofacial development (Mouse and Avian) 2 – 3D atlases that define the phenotypes of mutant, transgenic and morpholino-based knock-down embryos. 3 – Molecular atlases of gene expression in normal and experimentally perturbed embryos. 4 – Live 3D imaging of craniofacial development. Imaging Craniofacial Development

2 OPT SIM uMRI Volumetric Imaging Tools

3 Refined Processing for uMRI

4 Putting structures in context

5

6 Robust multiplexing of five target mRNAs in fixed whole-mount zebrafish H.M.T. Choi, J.Y. Chang, L.A. Trinh, J.E. Padilla, S.E. Fraser, N.A. Pierce, in review

7 Imaging Craniofacial Development 3-D imaging of anatomy volumetric data sets, tools 3-D imaging of gene expression volumetric data sets, tools 4-D imaging of development data sets, tools, pipeline Single cell in context is key

8 Digital dissections of wt & TGF k/o F

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