1. Date of download: 5/31/2016 Copyright © The American College of Cardiology. All rights reserved. From: Mechanical Thrombectomy for Acute Ischemic Stroke: A Meta-Analysis of Randomized Trials J Am Coll Cardiol. 2015;66(22):2498-2505. doi:10.1016/j.jacc.2015.09.070 Summary Plot: Good Functional Outcome More patients who had mechanical thrombectomy after usual care achieved a higher incidence of achieving good functional outcome (modified Rankin scale [mRS] 0 to 2) compared with usual care alone. The relative size of the data markers indicates the weight of each study’s sample size. CI = confidence interval; ESCAPE = Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times; EXTENDA-IA = Extending the Time for Thrombolysis in Emergency Neurological Deficits–Intra-arterial; IMS III = Third Interventional Management of Stroke; MR CLEAN = Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands; MR RESCUE = Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy; REVASCAT = Randomized Trial of Revascularization with Solitaire FR Device versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting within Eight Hours of Symptom Onset; RR = risk ratio; SWIFT PRIME = Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke; THERAPY = Randomized, Concurrent Controlled Trial to Assess the Penumbra System's Safety and Effectiveness in the Treatment of Acute Stroke; THRACE = Trial and Cost Effectiveness Evaluation of Intra-arterial Thrombectomy in Acute Ischemic Stroke. Figure Legend:

2. Date of download: 5/31/2016 Copyright © The American College of Cardiology. All rights reserved. From: Mechanical Thrombectomy for Acute Ischemic Stroke: A Meta-Analysis of Randomized Trials J Am Coll Cardiol. 2015;66(22):2498-2505. doi:10.1016/j.jacc.2015.09.070 Summary Plot: All-Cause Mortality Mechanical thrombectomy was associated with a trend toward reduced risk of all-cause mortality; the relative size of the data markers indicates the weight of each study’s sample size. Abbreviations as in Figure 1. Figure Legend:

3. Date of download: 5/31/2016 Copyright © The American College of Cardiology. All rights reserved. From: Mechanical Thrombectomy for Acute Ischemic Stroke: A Meta-Analysis of Randomized Trials J Am Coll Cardiol. 2015;66(22):2498-2505. doi:10.1016/j.jacc.2015.09.070 Mechanical Thrombectomy in Stroke: Functional Outcomes and All-Cause Mortality In patients with acute ischemic stroke due to large artery occlusion, mechanical thrombectomy was associated with a significantly higher incidence of achieving good functional outcome, defined as modified Rankin scale (mRS) 0 to 2, compared with usual care alone (p < 0.0001). Those who had mechanical thrombectomy also had a higher incidence of excellent functional outcomes (mRS 0 to 1; p < 0.0001) and fair functional outcomes (mRS 0 to 3; p = 0.001), and a trend toward lower all-cause mortality (p = 0.09). (Inset) Number needed to treat for the functional outcomes. Figure Legend: