1. Fig. 11-41 Nuclear Receptors

2. Fig. 11-40

3. Shiu et al. (1998) Cell 95:927-937 Estrogen Receptor LBD with agonist  -helix from interact- ing co- activator Estrogen Receptor LBD with antagonist Estrogen Tamoxifen

4. Fig. 11-44

5. Fig. 11-43

6.  galatosidase -Dex +Dex

7. -Dex +Dex  galatosidase

8. Fig. 11-27

9. Fig. 4-10

10. Fig. 11-45

11. Fig. 13-1 Signal transduction pathways from extracellular proteins and peptides through cell surface receptors to transcription factors

12. Fig. 13-32

13. N C Histone acetylase domain Domains that interact with activation domains CBP is a multidomain domain protein with several domains that bind to activator activation domains and one histone acetylase domain. It functions as a co-activator for many activators.

14. CREB Activation domain Domain of CBP

15. Fig. 14-16 EGF Receptor

16. Fig. 14-16

18. Fig. 14-21

19. Fig. 14-23

20. Hassler M, Richmond TJ EMBO J. (2001) 20:3018-28. (TCF)

21. serum PIC Assembly + serum serum + serum 23 AD

22. Fig. 11-24 Fos Jun

23. Nucleus Cytoplasm Plasmamembrane (Immuno- suppresor drugs)