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Medication Non-Adherence: The Hidden Epidemic

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Presentation on theme: "Medication Non-Adherence: The Hidden Epidemic"— Presentation transcript:

1 Medication Non-Adherence: The Hidden Epidemic
Managing Medication Adherence & A Safe Hospital Discharge

2 Incidence of Medication Noncompliance
50% of the 1.8 billion prescription medications dispensed annually in the United States are not taken correctly by patients Reference: Smith DL. The effect of patient noncompliance on health care costs. Medical Interface 1993;74-84. Intent of Slide: Increase audience awareness of the prevalence of medication noncompliance in the U.S. Expand upon the opportunities available for the pharmacist to intervene and increase medication compliance through patient counseling and follow-up. Adherence to Long-Term Therapies: Evidence for Action. WHO 2003 Smith DL - Med Interface 1993; 74-84

3 U.S. Patients Do Not Take Medications as Prescribed
100% 76%* 88% 47%* Rx prescribed Rx continued Rx taken Rx filled -12% -29% * 22% of U.S. patients take less of the medication than is prescribed This is a conceptual slide, based on statistics from the American Heart Association. Here you can see nonadherence broken down by behavior and quantified. As you can see, there is a progression of nonadherence that starts with not filling the prescription (12%). Then there are those that fill the prescription, but do not take the medication (12%). Then there are those who take the medication, but do not persist with it (29%). And within the percentage of patients that take their medications, there are 22% that take less than is prescribed. So according to this information, only 25% of those who are prescribed medication actually take it like they should. How does this affect patients? American Heart Association: Statistics you need to know. Accessed July 27, 2002.

4 Impact of Medication Adherence on Hospitalization Risk
The impact of medication adherence on the estimated all-cause hospitalization risk based on regression analysis. Results indicated that the outcome was significantly higher than the outcome for the % group (P<0.05) In the public debate over rising prescription drug costs the potential economic return s are often missed. These results demonstrate that a net return may be obtained for 3 chronic conditions that account for a large share of long term medication use. In this slide statistically significant different differences were seen in the hospitalization risk in patients that had a lower adherence level compared to those with adherence levels from % Other Notes: The study consisted of 137,277 patients under age 65 Measures included disease related and all cause medical costs, drug costs and hospitalization risk were measured. Using regression analysis these measure were modeled at varying levels of medication adherence. Medication adherence was defined by days’ supply of maintenance medications for each condition. *P<0.05 when compared to the % group Sokol etal. Med Care 2005;43:

5 Impact of Medication Adherence on All-Cause Healthcare Costs
The estimated all-cause healthcare costs based on regression analysis In the public debate over rising prescription drug costs the potential economic returns are often missed. These results demonstrate that a net return may be obtained for 3 chronic conditions that account for a large share of long term medication use. In this slide statistically significant different differences were seen in the hospitalization risk in patients that had a lower adherence level compared to those with adherence levels from % Other Notes: The study consisted of 137,277 patients under age 65. Measures included disease related and all cause medical costs, drug costs and hospitalization risk were measured. Using regression analysis these measures were modeled at varying levels of medication adherence. Medication adherence was defined by days’ supply of maintenance medications for each condition. *P<0.05 when compared to the % group + P<0.05 when compared to the % group in Diabetes and Hypercholesterolemia Patients Sokol etal. Med Care 2005;43:

6 Potential Barriers to Improving Adherence
Poor attitude Memory deficits Language Literacy Cultural beliefs Alternative health beliefs Poor support Pride Denial Fear or embarrassment Side effects Religious beliefs Unable to “see” results of drug therapy Lack of choices Cost Some of these barriers are more easily overcome than others. (i.e. support can be provided externally but cultural and religious beliefs are deeply ingrained and difficult to bridge). Vermiere E, et al. J Clin Pharm Ther ;26:

7 What is CMAG? Developed from concepts presented by the World Health Organization (WHO) Case Management Adherence Guidelines or CMAG provides an interaction and management algorithm to assess and improve the patient's knowledge and his/her motivation to take medications as they are prescribed. The guidelines provide great flexibility in that individual patient needs can be taken into account.     

8 WHO White Paper on Adherence
The World Health Organization has made a strong case that medication adherence is based on three pillars: patient information, motivation, and behavioral skill requirements. Adherence to Long-Term Therapies: Evidence for Action. WHO 2003

9 CMAG Algorithm Case Management Adherence Guidelines. Copyright© CMSA

10 Tools to assess patient knowledge
CMAG Assessment Tools Tools to assess patient knowledge Health Literacy – RealmR Medication Knowledge Survey Modified Morisky Scale

11 Health Literacy Health literacy is defined as the ability to read, understand, and act on health information. Poor health literacy results in medication errors, impaired ability to remember and follow treatment recommendations, and reduced ability to navigate within the healthcare system. The Rapid Estimate of Adult Literacy in Medicine-Revised (REALM-R), a brief eight-item screening test

12 Bass Pf, Wilson JF, Griffith, CH. J Gen Intern Med.2003;18:1036-1038.

13 Medication Knowledge Survey
Assesses knowledge of various medications to be taken, their dosing schedule, benefits and storage Useful as part of the knowledge assessment for CMAG to determine if the patient is in the high or low knowledge domain

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15 Tools to assess patient motivation
CMAG Assessment Tools Tools to assess patient motivation Readiness Ruler Duke-UNC Functional Social Support Questionnaire

16 Readiness Ruler Assess willingness to change behavior
Zimmerman GL, Olsen CG, Bosworth MF. Am Fam Physician.2000:61;

17 Social Support Family or social support is a significant predictor of adherence to long-term medical therapy Duke-UNC Functional Social Support Questionnaire Eight-item, self-administered, multidimensional instrument Broadhead WE, et al. Med Care.1989:27;

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19 Modified Morisky Scale
Patients on existing therapy Morisky 4 item validated adherence predictor scale Two new items to recognize patient understanding of medication benefits as well as refill behavior Allows patients to be categorized as either High or Low on Knowledge and Motivation domains Morisky DE, Green LW, Levine DM. Med Care. 1986;24:67-74.

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21 New to CMAG Revision Recognize unique needs of those working with inpatients
Hospital Discharge

22 The Hospitalized Patient
Acknowledges patients higher level of acuity Case managers may only be involved with a small percent of inpatients Case managers & Nurses have a decreased period of time to interact and plan interventions with patients Collaboration is important to ensure that the appropriate patients are referred to case management. Therefore, case managers need to work closely with other healthcare professional to ensure appropriate referral.

23 Successful Discharge Collaboration with other healthcare providers both within and outside the inpatient setting is extremely important to ensure a Successful Discharge

24 Steps to Ensure a Successful Discharge
Educate the patient and ensure patient understanding on their diabetes disease process and factors that can influence their condition Ensure the patient has the resources to manage their diabetes after discharge from the hospital Make certain that the discharge will be “safe” for the individual patient Ensure that the patient understands the plan for transition of care into the post discharge setting Make certain that the patient has access to the follow up care and therapy CMAG 2 has coined the term Successful Discharge for patients receiving appropriate Discharge Planning services. Patients that receive the appropriate steps that lead to a Successful Discharge will be more likely to manage their disease outside the hospital. This will decrease the chances of the person needing to be readmitted to the hospital for acute exacerbations of chronic conditions and complications related to procedures. Since hospitalization is frequently the most expensive part of the treatment, this should help control overall healthcare expenditures.

25 Information for Patients to Ensure a Successful Discharge
Patients that are educated regarding their diabetes and treatments are more likely to remain adherent to treatment recommendations Many patients discharged from the hospital will leave on new medications or different routes of administration

26 Information for Patients to Ensure a Successful Discharge
Medications that are newly started during hospitalization need to be reconciled with other medications Patients need to know how to monitor their diabetes and treatment in an outpatient setting.

27 Questions Addressed With Patients Prior To Discharge
What is wrong with me and what will this condition mean to my long-term health? What do I need to do when I get home to treat my condition? Who should I contact if I have questions regarding my treatment after I am discharged? What are things that I need to watch for to know if my condition is getting worse and what should I do if these occur? How will I pay for my outpatient medical supplies or services?

28 Why discharge counseling and adherence messaging are important for the hospital?
Maintain Accreditation JCAHO, NCQA, CMS Successfully compete with other hospitals in the community Patient satisfaction Publicly available quality rankings Financial Prevent readmissions Promote timely patient discharges

29 Competitive Advantage for Hospital Discharge Planning
Hospitals seek to be viewed as providing an outstanding level of care Hospitals work to maintain a high level of patient satisfaction Discharge counseling is one of the last points of contact with the patient Patients and payers can now easily compare quality indicators on hospitals in their community

30 Current State of Hospital Discharge Counseling and Adherence Messaging
Studies of patients recently discharged from the hospital have found that: < 50% of patients could state their diagnosis < 50% of patients could list all their medications < 25% of patients could state common side effects and what to expect from their medications, Patients taking three or more medications were more likely to have problems with medication knowledge King, 1998; Makaryus, 2005

31 Key Elements of Successful Discharge Planning
Recruit a champion Build a multidisciplinary hospital team Review baseline data Develop protocols and order sets that include appropriate evidence-based therapies Conduct hospital staff conferences to introduce process and gain buy in Continue data analysis and report results back to hospital staff on a regular basis Evaluate data and look for opportunities for improvement Create an adherence program AHA, Get with the Guidelines

32 Coordination of Care and Transition of Care Outside the Hospital
There are many individuals that may be involved in the discharge planning process. These individuals can be divided into lay individuals that provide support for the patients and those that are involved with the provision of healthcare services.

33 Transition of Care to the Outpatient Setting
Involve family and caregivers in patient education Ensure that patient has a plan for outpatient follow up Facilitate referral for outpatient services and healthcare providers Assist patients with resolving issues relating to the cost of outpatient services and treatments Evaluate Adherence Intention prior to discharge using CMAG tools Involvement of family and friends especially important for interventions involving lifestyle modifications.


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