1. HOUSING Division Corporate Marketing Department

2. Plastic Materials POLYETHERIMIDE (PEI) POLYSULFONE (PSU) PSU 3 years WARRANTY PEI 5 years WARRANTY

3. 1291H (Same cage) Floor area 800 cm 2 1145T (Shoe box cage) Floor area 435 cm 2 1285L (Type II Long) Floor area 542 cm 2 Housing Flexibility Floor Area

4. Cage Sealing NYLON GASKET all around the LID WITHOUT the LATCHES the TOP just leans on the CAGE BASE !!! The user friendly CLAMPS provide the needed FORCE to ensure a secure seal between top cover and cage base TOP LID BASE

5. Air Path & Air Speed Accordingly with all the scientific evidences & the new US Guideline 2010 – eight edition – both the AIR INLET and OUTLET are located in the rear TOP of the CAGE Max air speed at animal level = 0,05 m/s << 0,2 m/s (suggested threshold) Animal Stress Animal Heat Loss

6. Cage Base The CAGE BASE is SYMMETRIC NO WASTE of TIME finding the correct SIDE Time & Effort During cage change procedures

7. Stackability Cage Base Stacking lug10 cages in a stack … 1145T = 71 mm773 mm 1291H = 67 mm784 mm 1285L = 41 mm499 mm

8. Visibility Excellent Visibility inside the cage !!! Time & Effort During daily check operations

9. Lid Style EASY PUSH AND PULL Accessibility to the animals

10. FOOD HOPPER with food accessibility on 3 SIDES Food accessibility for the animals Animal Welfare Lid Style

11. Bottle Depression EXTERNAL WATER BOTTLE SELF-CENTERING BOTTLE DEPRESSION Time & Effort During bottle change procedures Animal Stress

12. Water Bottle 3 lips SILICON GASKET around the BOTTLE NECK CONE-shaped BOTTLE CAP Prevent water from leaking Water availability for the animals

13. Filter Top (Filtration Media) MICROBIOLOGICAL FILTER VFE* and BFE** ≥ 99.999987% *VFE= Virus Filtration Efficiency **BFE= Bacteria Filtration Efficiency Cage Sealing Gases Exchange Mice in healty condition even after 48h of NO VENTILATION Allergens at room level

14. Rack Style VERTICAL AIR DISTRIBUTION PLENUM Time & Effort During washing procedures !!! Washing Performance Exhausted particles (bedding, hairs, debrees, …) fall down by gravity in the vertical plenum without occluding them BEDDING MATERIALS & DUST TRAPPED INSIDE THEM

15. Rack Style ROUNDED CORNERS DESIGN Risk of injuries for the operators Ergonomics Risk of damage the wall

16. Filter Top (Valves) AIR NOZZLES remain OUTSIDE the CAGE SILICON O-RING around the VALVES Cage Sealing NO possibility of CROSS-CONTAMINATION between cages

17. Washing & Autoclaving EASY TO BE DISASSEMBLED FOR WASHING TOOLS FREE PROCEDURE - Remove Nozzles & blue caps - Remove the main horizontal plenum - Disconnect the rack from the AHU 7 mins and 1 operator needed !!! - 75 % Running costs compared to the main competitors

18. Automatic Watering System Blue Line NEXT racks are either factory fitted or retrofittable with any Automatic Watering System Standard AWS configuration: Water INLET and OUTLET both on the right end side of the rack

19. Density 9 levels high as standard 6 levels high as standard 108 cages/m 2 35 cages/m 2 9 levels high as standard 86 cages/m 2

20. Rack Style It flags any cage that is not fully docked. When a cage is fitted properly into the rack, the flag disappears from view (NO flag? No problem!) VISUAL INDICATOR SELF LOCKING SYSTEM The rack runners have built-in stoppers that fit the stopping lugs precisely, so each cage stops and locks silently into place automatically SAFETY With NO Effort for the operators

21. Air Handling Unit Low ENERGY consumption & HEAT emission Plastic Cover Light & Ergonomic User-friendly interface at eye level HEPA filtration efficiency through DOP TEST Needed force to move < 35 N Running costs Safety for animals & operators Eco-friendliness Effort for the operators

22. MULTILINKING CAPACITY Air Handling Unit Up to 2 Double Sided or 4 Single Sided Racks RACK # 1RACK # 2 SUPPLY PLENUM EXHAUST PLENUM Pressure drop Homogeneity of the intra-cage parameters across the rack

23. Possibility to selectively remote the ALARM !!! (Settable range of alarm for each parameter) Wi-Fi software package that monitors and controls remotely all the working conditions of the AHUs and keeps a constant record of the parameters. Air Handling Unit

24. UNI EN ISO 9001:2008 UNI EN ISO 14001:2004 ENVIRONMENTAL REPORT (according to ISO 14025) CO 2 FOOTPRINT (according to PAS 2050) MEMBER of the GREEN BUILDING COUNCIL ITALIA PRODUCT LIFE CYCLE ASSESSMENT (LCA) (ISO 14040:2006 / ISO 14044:2006) ISO 9001 – Cert. n° 0875ISO 14001 – Cert. n° 0256A/0

25. HOUSING Division Corporate Marketing Department