1. Tissue Repair

2. Animation to Begin…

3. After Tissue Injury… Capillaries become very permeable
Clotting proteins – form a clot / scab
Nutrients – healing process
Granulation tissue forms
New capillaries grow into area
Phagocytes – consume blood clot
Fibroblasts – collagen fibers (scar tissue)
Regeneration and/or fibrosis
Growth of replacement tissue
Scab detaches
Scar (fibrosis) may be visible

4. Regeneration vs. Fibrosis
Regeneration = replacement by same type of tissue
Fibrosis = replacement by scar tissue
Made of dense c.t. (collagen fibers)
Strong but less flexible & less elastic
Depends on location & severity of wound

9. Ability of Tissues to Regenerate
Regen. well: epithelial & most conn. tissues
Moderate regen: dense c.t. & smooth muscle
Weak regen: skeletal muscle & cartilage
No regen: cardiac muscle & nervous tissue (brain & SC)
Replaced by scar tissue (fibrosis)
Affects function (ex: multiple heart attacks)