1. EYE DOSAGE FORMS Author: ass. Yu.Yu. Plaskonis

2. Classification of eye medical forms solid liquid soft gaseous

3. Solid medical forms: pills, lamels, pencils, powders, tapes. Liquid medical forms: eye drops, washes, washings, solutions for injections and electrophoresis. Soft medical forms: ointments homogeneous and heterogeneous. Gaseous medical forms: aerosols.

4. Eye drops (Guttae ophthalm і cae ) - are medical form, which shows by itself hydrogen's or oil solutions, and also suspensions which are intended for installation in a conjunctive sac in a negligible quantity.

5. Requirements for eye drops: sterility isotonicity stability exactness of concentration of operating substances; transparency; absence of irritating and allergenic actions to find out maximal biological activity in some cases do prolonged therapeutic effect.

6. Aseptic terms - it the certain terms of work, and also complex of obligatory organizational measures which allow maximally to save medications, from a hit in them of microorganisms.

7. Sterility - arrived at by preparation of eye drops in aseptic terms and their next sterilization.

8. Stability is arrived by the use of buffer solutions, stabilizations and by the correct selection of tableware, made from glass of brand NG (neutral glass)-1, NG-2, NG-3.

9. Absence of mechanical inclusions provided by filtration

10. Isotones of eye drops conduct on principle of the same name of ions. Use: sodium chloride sodium sulfate sodium nitrate boric acid (only on a concordance with a doctor) glucose (only on a concordance with a doctor)

11. For isotones use the isotonic equivalents of medicinal substances by sodium chloride. Rp.: Sol. P і locarp і n і hydrochlor і d і 1% 10 ml і soton і cae D. S. For 2 drops in eyes

12. Е = 0,22. 1,0 pilocarpine - 0,22 sodium chloride 0,1 pilocarpine - Х =0,022 0,9 sodium chloride isotones 100 ml of water Х -10 ml Х= 0,09 g Determine the amount of sodium of chloride, necessity for isotones of 1% solution of Pіlocarpіnі hydrochlorіdі 0,09 - 0,022 = 0,068  0,07 g

13. Technology depends on solubility of substances If a medical substance is well soluble in a solvent, dissolve in the half amount of solvent and filter in a small bottle for dispense through washed by water purificate filter and cotton wool, and then a filter washed by other part of solvent.

14. Technology depends on solubility of substances If a medical substance is difficult soluble, dissolve in totally of solvent and filter in the measured cylinder through a dry filter and cotton wool, and amount of water, that it is not enough, add through the same filter and cotton wool to the necessary volume of solution.

15. Rp.: Sol. Zinci sulfatis 0,25 % 20 ml M. D. S. For 2 drops in an eye. WCP (r.s.) Zinci sulfatis 0,05 Aque purificatae 20 ml Natrii sulfatis 0,76

16. а ) with the use of equivalents of zinc sulfate and sodium sulfate at sodium by a chloride: Amount of zinc sulfate : 0,25 - 100 ml Х - 20 ml Х = 0,05 Amount of sodium of chloride which equal the amount of zinc sulfate : 1,0 - 0,12 0,05 - ХХ = 0,006 4. Amount of sodium chloride, necessity for isotones of eye drops: 0,18 - 0,006 = 0,174 Amount of sodium sulfate, necessity for isotones of eye drops : 0,23 sodium chloride - 1,0 sodium sulfate 0,174 sodium chloride – Х Х = 0,76

24. WCP (f.s.) Date № of recipe Aquae purificatae 10 ml Zinci sulfatis 0,05 Natrii sulfatis 0,76 V = 20 ml 10 ml № 2 Sterilis Prepared Checked Registration to dispense. Labels: the "Eye drops", "Sterile", to "Save from children".

25. Rp.: Ung. Thiamini bromidi 0,5% 10,0 D. S. To mortgage for an eyelid. WCP (f.s.) Date № of Thiamini bromidi 0,05 (0,1) Aquae purificatae q.s. Basis pro oculi sterile (8:2) 10,0 m = 10,0 Addita aseptice Prepared Checked

29. THANK YOU FOR ATTENTION!!!