1. + “You’ll Never Walk Alone” Duchene Muscular Dystrophy By Zsanell Go http://trialx.com/curetalk/wp- content/blogs.dir/7/files/2011/05/diseas es/Limb_Girdle_Muscular_Dystrophy- 2.jpg http://www. glogster.co m/media/5 /28/8/68/28 086899.jpg

2. + Thesis Statement “With the help of supporters, modern research advances in therapeutic management of Duchene muscular dystrophy increase survival and quality of life of today’s patients and bring realistic optimism towards its ultimate cure for the next generation.” http://hcms-renaissance-research.wikispaces.com/file/view/thesis_funnel.png

3. + Introduction Discuss Jerry Lewis’ dedication to the Muscular Dystrophy Association (MDA). http://upload.wikimedia.org/wikipedia/co mmons/thumb/1/1d/Jerrylewis2.jpg/220px- Jerrylewis2.jpg http://top- people.starmedia.com/tmp/swotti/cacheAMVYCNKGBGV3AX M=UGVVCGXLLVBLB3BSZQ==/imgJerry%20Lewis5.jpg

4. + Intro +: Darius Goes West! Add this equally inspiring experience of Darius Weems, who he himself experienced Duchene Muscular Dystrophy. http://www.beersteak.com/wp- content/uploads/2009/03/darius-goes- west.jpg http://blog.syracuse.com/news/2009/03/ Darius.JPG

5. + Brief definition & Detection/ Diagnosis Duchene muscular dystrophy is a progressive muscular disease caused by the deficiency of dystrophin, a muscle protein, leading to complete loss of ambulation and death by heart or pulmonary deterioration in the late teens or early twenties. How to determine what causes MD. Scientific Analysis. http://2.bp.blogspot.com/- hD9ljnGZGb8/TaHG71_hTDI/AAAAAAAAABI/bSIgC8gOpqA/s1600/chr omosome100806.jpg

6. + Symptoms of DMD In as early as the preschool years, boys with DMD will experience trouble standing or walking, Muscle weakness, & enlarged calves called pseudohypertrophy. http://www.brightestbeginnin gs.com/images/0327hop.jpg

7. + Progression of Symptoms Additional common symptoms include scoliosis, toe-walking, and permanent shortening or deformity of the ankles, knees, and hips. By ages 8 to 13 years of age, they would be unable to walk and require wheelchairs. http://www.netterimages.com/images/vpv/000/000 /001/1135-0550x0475.jpg http://www.nlm.nih.gov/medlineplus/images/muscles.jpg

8. + Future Treatment Possibilities: What advances in Research/Treatments/Cure/Clinical Trials? Doctors worldwide have made encouraging breakthroughs like: Glucocorticoid corticosteroid therapy, Myoblast transplantation, Genetic and pharmacologic therapy, & axon skipping method. http://www.isteroids.com/blog/wp - content/uploads/2009/09/steroids- may-have-greater-impact-on- diabetics-200x168.jpg http://fuchsiawoman.co m/wp- content/uploads/2011/06 /glia5-300x300.jpg

9. + Conclude! Restate of thesis & brief note to leave the reader with. How can we help and be the vehicle towards the cure? Lewis and Weems changed the lives of those with DMD and so can we. “The big fat road connects us all.” Understand DMD Make a donation Sponsor a DMD screening test Support fundraisers like purchasing an award-winning DVD Darius Goes West