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34 Fig 2: Da Devare SG, J Med Virol 2007 Fig 2: Da Devare SG, J Med Virol 2007

35 Da Nick et al, J Med Virol 2007

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45 Period of declining new HIV diagnoses in BC coincident with increased HIV testing rates, increased uptake of antiretroviral therapy, and decrease in community viral load ( ) – Decline in new HIV diagnoses despite increases in syphilis, gonorrhea, chlamydia Montaner J, et al. CROI Abstract 88LB. Reproduced with permission ,000 10,000-49, < 500 Reduction in New HIV Diagnoses in BC: Testing, HAART, and Community VL ,000 12,000 Censored at the time of death or move Patients (n) HIV-1 RNA, copies/mL New HIV+ diagnoses (all) New HIV+ Diagnoses (n)

46 The decline of HIV DNA values during an effective therapy was directly related to baseline HIV DNA and HIV RNA values at baseline, to the increase in the number of CD4 cells to the achievement of a HIV RNA load <2.5 copies/ml. Undetectable HIV DNA cellular load was achieved by 21.6% of patients at the follow-up time point and significantly correlated with lower baseline cellular HIV DNA values and being in the primary stage of infection when therapy started. In conclusion, early treatment facilitated the achievement of undetectable levels of plasma viraemia and cellular HIV DNA and a better recovery of CD4 lymphocytes. HIV DNA level before and during highly active antiretroviral therapy may be used as a new tool for monitoring treatment efficacy Parisi et al, J Clin Microb 2012

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48 296 soggetti studiati alla diagnosi per resistenze nellanno 2009 in Veneto Mediana anni39 (18-79) 18 anni1 (1fs) (2fs, 1ms) 216 (4mi, 2fs) 222 (2mi) 234 (3mi, 1fs) 248

49 303 soggetti studiati alla diagnosi per resistenze nellanno 2010 in Veneto Mediana anni39 (17-72) 17 anni1ms 192 (1mi, 1ms) 201 (1ms) 217 (2mi, 1f1, 4fs) 221 (1ms) 237 (4mi, 1fi, 1ms, 1fi) 245 (3mi, 1ms, 1fs)

50 245 soggetti studiati alla diagnosi per resistenze nellanno 2011 in Veneto Mediana anni38 (19-66) 18 anni 191fi (2mi, 1fs) 224 (2mi, 1fi, 1fs) 232 (1mi, 1fs) 247 (1mi, 3ms, 3fs)

51 Parisi et al, CAVeAT 2013

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54 Distribuzione mondiale dei sottotipi HIV A (1519) B (16067) C (737) CRF01_AE (625) CRF02_AG (51) CRF03_AB (84) D (369) F (173) G (229) H (21) J (8) N (1) K (3) O (113) Other recomb. (178)

55 Sottotipi HIV-1 in Africa ( ) Costa davorio CiadCamerun Sud Africa Zambia Gabon DRC Uganda Kenya TanzaniaEtiopia Senegal Mali Niger Benin Nigeria

56 Parisi et al, CAVeAT 2013

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59 GRAZIE PER LATTENZIONE Paulus Furst 1656: illustration of protective clothing against plague


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