1. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy

2. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 22 Pharmacology of Hemostasis and Thrombosis Chapter 22 Pharmacology of Hemostasis and Thrombosis

3. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Sequence of Events in Hemostasis Figure 22-1

4. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Platelet Adhesion and Aggregation Figure 22-2

5. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Platelet Activation Figure 22-3

6. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Platelet Activation by Thromboxane A 2 Figure 22-4

7. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Platelet Activation by ADP and Thrombin Figure 22-5

8. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Coagulation Cascade Figure 22-6

9. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Coagulation Factor Activation on Phospholipid Surfaces Figure 22-7

10. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Central Role of Thrombin in the Coagulation Cascade Figure 22-8

11. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Antithrombin III Action Figure 22-9

12. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins The Fibrinolytic System Figure 22-10

13. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Virchow’s Triad Figure 22-11

14. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Overview of Prostaglandin Synthesis Figure 22-12

15. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Mechanism of Action of Antiplatelet Agents Figure 22-13

16. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Mechanism of Action of Warfarin Figure 22-14

17. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Differential Effects of Unfractionated Heparin, Low-Molecular- Weight Heparins, Selective Factor Xa Inhibitors, and Direct Thrombin Inhibitors on Coagulation Factor Inactivation Figure 22-15