2. 1 3/12/2016 Acquired Immunity Hugh B. Fackrell filename : Kuby 01B7

3. 2 3/12/2016 Acquired Immunity: Outline Acquired Immunity: Outline äAäAäAäAcquired vs Innate Immunity äFäFäFäFunctions of Acquired Immunity äHäHäHäHumoral Immunity: antibody äCäCäCäCell Mediated Immunity äRäRäRäRole of Macrophages RRRRegulation of Immunity äNäNäNäNext

4. 3 3/12/2016 Acquired Immunity: Definitions äAäAäAäAcquired Immunity äAäAäAäAntigen äIäIäIäImmunogen äHäHäHäHumoral Immunity äCäCäCäCell Mediated Immunity äNäNäNäNext

5. 4 3/12/2016 Acquired Immunity: Objectives ä Define the following terms: Antigen, immunogen, acquired immunity, humoral immunity, cell mediated immunity ä Identify the cells of the acquired immune response from light or electron micrographs ä Identify the functions of the cells of the acquired immune reponse ä Next

6. 5 3/12/2016 Acquired Immunity ä Definition ä Acquired immunity( AKA adaptive immunity) is an altered reactivity to a specific compound after exposure to that compound ä Characteristics ä Specificity ä Memory ä Next

7. 6 3/12/2016 Acquired Immunity Important Features ä The altered reactivity will not be to all compounds, just those compounds to which the animal has been exposed ä The animal has a heightened specific response on second and subsequent exposures because the body ” remembers” previous contacts  Next

8. 7 3/12/2016 Functions of Acquired Immunity Discriminate between self and non self for: ä Defense ä destruction ä destruction of foreign molecules ä Homeostasis ä removal ä removal of dead or damaged cells ä Surveillance ä control ä control of mutant or cancer cells ä Next

9. 8 3/12/2016 Acquired Immunity has Two Forms ä Humoral Immunity ä lymphocytes react INDIRECTLY on non self molecules via antibodies ä Cell Mediated Immunity ä Lymphocytes act DIRECTLY on the non self molecules ä Next

10. 9 3/12/2016 Lymphocytes

11. 10 3/12/2016 Immunogen vs Antigen ANTIGEN: combines with the products of an immune response IMMUNOGEN: triggers immunity and combines with products

12. 11 3/12/2016 Antigen: interaction

13. 12 3/12/2016 Remember ä Immunogenicity is not an inherent characteristic of a molecule ä Immunogen MUST first be recognized as foreign by the body ä Next

14. 13 3/12/2016 Adaptive vs Innate Immunity

15. 14 3/12/2016 Primary vs Secondary Responses

16. 15 3/12/2016 Humoral Immunity Humoral Immunity

17. 16 3/12/2016 Antibodies Distinguish Between ä Diseases ä measles & mumps ä Macromolecules ä proteins, complex carbohydrates ä Molecules ä amino acids, sugars ä Submolecular Structures ä D& L isomers; ortho, meta, para positions ä Next

18. 17 3/12/2016 B cell blasts

19. 18 3/12/2016 B Cell Transformation

20. 19 3/12/2016 Clonal Selection: B cells

21. 20 3/12/2016 Immunglobulin on B cells

22. 21 3/12/2016 Plasma cell function

23. 22 3/12/2016 Antibody: a Flexible mediator

24. 23 3/12/2016 Plasma cell: function

25. 24 3/12/2016 Complement functions

26. 25 3/12/2016 Cell Mediated Immunity Cell Mediated Immunity

27. 26 3/12/2016 T cell blasts

28. 27 3/12/2016 T cell blasts: structure

29. 28 3/12/2016 T cells

30. 29 3/12/2016 Cell mediated clonal selection

31. 30 3/12/2016 T cell transformation

32. 31 3/12/2016 T cells ANAE stain

33. 32 3/12/2016 Role of Macrophages Role of Macrophages

34. 33 3/12/2016 Monocyte

35. 34 3/12/2016 Monocyte structure

36. 35 3/12/2016 Macrophage Activation products

37. 36 3/12/2016 Macrophages & T cells

38. 37 3/12/2016 T cells interacting with Macrophage

39. 38 3/12/2016 Macrophage mediatiors: CD14 receptor

40. 39 3/12/2016 Macrophage mediators: CD14 & LPS receptors

41. 40 3/12/2016 Endotoxin induction of Macrophage mediators: direct induction

42. 41 3/12/2016 Oponsization: mechanisms

43. 42 3/12/2016 Regulation of Immunity Regulation of Immunity

44. 43 3/12/2016 Range of immune responses

45. 44 3/12/2016 Antigen Processing

46. 45 3/12/2016 Cellular interactions during the humoral response

47. 46 3/12/2016 A Complete Immune Response ä Lymphocytes ä B cells ä T cells ä Macrophages ä critical accessory cells ä Complement ä combines with antibody to enhance destruction ä Next

48. 47 3/12/2016 White Blood Cells

49. 48 3/12/2016 Adverse effects of Immunity

50. 49 3/12/2016 The End

51. 50 3/12/2016 Acquired Immunity: Questions ä How does clonal selection contribute to memory in the immune response? ä Name three feature of a secondary immune response that make it different from a primary immune response.

52. 51 3/12/2016 Questions(1) ä Interleukin 2 is a nonspecific growth factor that stimulates the growth of TH cells during the immune response. In view of this nonspecificity of IL-2, what mechanism assures that only TH cells specific for a given antigen proliferate and that all other TH cells do not proliferate

53. 52 3/12/2016 Questions (2) ä Antigen presenting cells play a role in both humoral and cell mediated immune responses ä Name three type af antigen presenting cells ä Which class of MHC molecules are expressed on the membrane of antigen presenting cells? ä Which lymphocytes interact eith antigen presenting cells?