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Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers Gurushankar Chandramouly, Shane McDevitt, Katherine.

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Presentation on theme: "Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers Gurushankar Chandramouly, Shane McDevitt, Katherine."— Presentation transcript:

1 Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers Gurushankar Chandramouly, Shane McDevitt, Katherine Sullivan, Tatiana Kent, Antonio Luz, J. Fraser Glickman, Mark Andrake, Tomasz Skorski, Richard T. Pomerantz Chemistry & Biology Volume 22, Issue 11, Pages 1491-1504 (November 2015) DOI: 10.1016/j.chembiol.2015.10.003 Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

2 Figure 1 Chemistry & Biology 2015 22, 1491-1504DOI: (10.1016/j.chembiol.2015.10.003) Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

3 Figure 2 Chemistry & Biology 2015 22, 1491-1504DOI: (10.1016/j.chembiol.2015.10.003) Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

4 Figure 3 Chemistry & Biology 2015 22, 1491-1504DOI: (10.1016/j.chembiol.2015.10.003) Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

5 Figure 4 Chemistry & Biology 2015 22, 1491-1504DOI: (10.1016/j.chembiol.2015.10.003) Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

6 Figure 5 Chemistry & Biology 2015 22, 1491-1504DOI: (10.1016/j.chembiol.2015.10.003) Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

7 Figure 6 Chemistry & Biology 2015 22, 1491-1504DOI: (10.1016/j.chembiol.2015.10.003) Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

8 Figure 7 Chemistry & Biology 2015 22, 1491-1504DOI: (10.1016/j.chembiol.2015.10.003) Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

9 Chemistry & Biology 2015 22, 1491-1504DOI: (10.1016/j.chembiol.2015.10.003) Copyright © 2015 Elsevier Ltd Terms and Conditions Terms and Conditions

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