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Cardiovascular effects of anti-hyperglycemic therapy Edoardo Mannucci Diabetes Agency Careggi teaching hospital, Firenze, Italy.

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Presentation on theme: "Cardiovascular effects of anti-hyperglycemic therapy Edoardo Mannucci Diabetes Agency Careggi teaching hospital, Firenze, Italy."— Presentation transcript:

1 Cardiovascular effects of anti-hyperglycemic therapy Edoardo Mannucci Diabetes Agency Careggi teaching hospital, Firenze, Italy

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3 ADVANCE

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6 MACE CV mort.

7 Effects of intensified glycemic control on CV mortality

8 MYOCARDIAL ISCHEMIA Adrenercic activation could have a negative impact on the prognosis of

9 MACE

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11 Secondary prevention of macrovascular events in patients with type 2 diabetes: The PROACTIVE Study Dormandy JA et al., Lancet 2005; 366: 1279

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13 Relative risk SU vs other therapies vs. Conventional vs. Insulin vs. Metformin Mortality0.961.031.53 MI0.830.911.24 Stroke1.191.402.12

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15 Effect of SU on MACE Monami M, Ganovese S, Mannucci E – 2013 [in press]

16 Effect of SU on mortality Monami M, Ganovese S, Mannucci E – 2013 [in press]

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