1. 1 Centre for Medical Image Computing (CMIC) University College London David Atkinson

2. 2 UCL Hospital Centre for Advanced Biomedical Imaging Inst. Hepatology Queen Square Inst Neurology, National Hospital Neuro. Functional Imaging lab, Dementia Research Centre Advanced MRI lab. Inst. Child Health Great Ormond Street London Centre for Nanotechnology Centre for Medical Image Computing

3. 3 6 academic staff ~ 50 PostDocs and PhD students. Majority with backgrounds in Computing, Maths, Engineering, Physics, Biomedicine.

4. 4 Research Highlights Image Registration Image Segmentation MRI Motion Correction MRI Flow measurements High Resolution Diffusion MRI Guided Prostatectomy

5. 5 Image Registration Non-rigid registration –Fast Free-Form Deformation –Parallelized for NVidia Graphics card. –<1 minute for 3D registration –Nifty Reg http://sourceforge.net/projects/niftyreg/ http://sourceforge.net/projects/niftyreg/ M. Modat, et al., Fast free-form deformation using graphics processing units, Comput. Methods Programs Biomed. (in press)

6. 6 Image Registration Alignment of DCE-MRI liver images. –PPCR algorithm aligns successive breath- hold images in the presence of contrast changes. No correctionFluid-based registrationPPCR Melbourne et al Phys Med Biol, 2007, 52:4805-4826

7. 7 Image Segmentation Whole heart segmentation using atlas and free-form deformation registration Zhuang et al. FUNCTIONAL IMAGING AND MODELING OF THE HEART, PROCEEDINGS 5528 p303-311

8. 8 MRI Motion Correction Training phase gives motion model Enables motion correction of higher resolution data. White et al Magn. Reson. Med. 62 p440 (2009)

9. 9 MRI Motion Correction Cardiac cine without ECG or breath- holding. Uses k y =0 navigator and 32 channel coil. Odille et al. Magn. Reson. Med. (in press) CorrectedNo correction

10. 10 Real-time flow Steeden et al. ISMRM Workshop Sintra 2009 Undersampled real-time spiral acq. Reconstruction on console

11. 11 High Resolution Diffusion MRI Multi-shot sequences and reconstruction. trace-weightedMDFA Porter et al. ISMRM 2008

12. 12 MR Guided Endoscopic Prostatectomy

13. 13 Overlay of MRI on Endoscopic view

14. 14 and more … Breast supine MRI to prone operation. Image directed prostate ablation. Motion modelling for lung radiotherapy. Tissue biomechanical modelling. Inverse Problems. Tissue microstructure from MRI. –axonal radius and density from DTI-type acq. Interactive MRI reconstructions using graphics cards. –trading spatial and temporal resolution.