1. بسم الله الرحمن الرحيم Medical mycology
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2. Examples of Mycoses Aspergillosis
Aspergillosis is the name of a range of infections caused by a fungal mould called aspergillus. It usually affects the lungs, but it can spread to almost anywhere in the body.
Aspergillosis usually only affects people with existing health conditions. Most healthy people have natural immunity to the aspergillus mould. If someone with damaged lungs or a weakened immune system breathes in aspergillus spores, the infection is more likely to stay.

3. Types of aspergillosis There are several forms of aspergillosis :
allergic bronchopulmonary aspergillosis
aspergilloma
invasive pulmonary aspergillosis
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4. Allergic bronchopulmonary aspergillosis (ABPA)
is caused by an allergic reaction to spores of fungus mould. It is the mildest form of aspergillosis.
ABPA usually affects people with asthma or cystic fibrosis. It is estimated to affect 0.25–0.8% of people with mild to moderate asthma, and 7% of people with cystic fibrosis.
ABPA affects an estimated 7–10% of people with more severe asthma that can only be controlled with steroid medication.
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5. Symptoms allergic bronchopulmonary aspergillosis, include: - Fever
-A cough that may bring up blood
-Worsening asthma
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7. allergic bronchopulmonary aspergillosis

8. Aspergilloma
Aspergilloma is common in people who have cystic fibrosis or cavities (spaces) in their lungs. Coughing up blood is one of the most common symptoms of aspergilloma.
Aspergillus fungi enter the lungs and group together to form a dense knot of fungi, called a fungal ball.
Aspergilloma usually only affects people who have an existing lung condition, such as tuberculosis (TB), which means that they have cavities or damage in their lungs.
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9. Symptoms Aspergilloma
-Coughing up blood breathlessness weight loss Fatigue
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10. Aspergilloma

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12. Invasive pulmonary aspergillosis (IPA)
IPA is a fungal infection in the lungs that spreads rapidly through the body. The infection can spread to the blood, brain, heart and kidneys.
IPA usually only affects people with a severely weakened immune system, such as:
people with end-stage HIV
people undergoing high-dose chemotherapy
people taking immunosuppressants because they have had an organ or bone marrow transplant
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13. Symptoms invasive aspergillosis can cause:
-coughing up blood breathlessness chest pain
-headaches Severe bleeding from lungs
- Fever
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14. invasive aspergillosis

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16. Aspergillus fumigatus A. flavus A. nige A. nidulans A. terreus
The most common cause is.
Aspergillus fumigatus
A. flavus
A. nige
A. nidulans
A. terreus

17. Aspergillus fumigatus

18. Aspergillus fumigatus

19. A. niger

20. A. niger

21. A. flavus

22. A. flavus

23. Diagnosis
chest X-ray :CT scan

24. Galactomannan (a molecule from the fungus that is sometimes found in the blood)
Immunoglobulin E (IgE) blood level
Lung function tests
Sputum stain and culture for Aspergillus
Tissue biopsy.

25. Treatments How is aspergillosis treated?
Allergic bronchopulmonary aspergillosis (ABPA) is usually treated with steroid medications to prevent an allergic response. However, if ABPA reoccurs, a long-term course of steroids may be required.
aspergilloma can be treated with antifungal medications. In some cases, surgery may be required to remove the infection from the lungs.
Invasive pulmonary aspergillosis (IPA) can be treated with antifungal medication, although it is difficult to treat. The infection can spread very quickly, and someone who develops IPA is usually already very ill. An estimated 50% of people do not respond to treatment and die from the condition
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