1. Genetic Disorders Review

2. What is the disorder? Chromosome 11 Inability to manufacture melanin
Often shifting back and forth of eyes
ANSWER: ALBINISM

3. What is the disorder? Polygenic More common among Asians
Opening in lip and roof of mouth
ANSWER: cleft lip/cleft palate

4. What is the disorder? Sex-linked trait Lack AHF factor
“bleeder’s disease:
ANSWER: hemophilia

5. What is the disorder? Chromosome #4
Too many copies of CAG – causes atrophy of the brain
Does not manifest itself until 20’s-30’s
ANSWER: Huntington’s

6. What is the disorder? On X-chromosome Weakening of muscles
Calf muscles enlarge first, usually in young boys
ANSWER: Duchenne Muscular Dystrophy

7. What is the disorder? Chromosome #15
Accumulation of fat on the brain leads to degeneration of the nervous system
Highest in Eastern European Jews
ANSWER: Tay Sachs

8. What is the disorder? Nondisjunction XXY
Sterile, small testes, breast enlargement in males
ANSWER: Klinefelters

9. What is the disorder? Nondisjunction Trisomy 21
Mental retardation, round face, extra fold on eyes, sluggish muscles
ANSWER: Down Syndrome

10. What is the disorder? Chromosome #12
Breakdown of products of phenylalanine
Mental retardation if diet does not omit phenylalanine
ANSWER: PKU

11. What is the disorder? Red blood cells collapse
Carriers are somewhat resistant to malaria
Found mostly in African-Americans and people of Mediterranean
ANSWER: sickle-cell anemia

12. What is the disorder? Nondisjunction Female XO, sterile
Web between neck and shoulders
ANSWER: Turner Syndrome

13. What is the disorder? Sex-linked trait XcY would be affected male
Inability to detect certain colors
ANSWER: color blindness

14. What is the disorder? Dominant chromosome #4
Short stature, trident hand, prominent forehead
Dwarfism Aa
ANSWER: Achrondroplasia

15. What is the disorder? Dementia Memory loss, confused
Plaque on the brain
ANSWER: Alzheimers

16. What is the disorder? Long limbs, enlarged aorta Spidery fingers
Abe Lincoln had it
ANSWER: Marfans

17. What is the disorder? Polygenic trait
Shunt in brain to drain off fluid
Opening of the vertebral column
ANSWER: Spina bifida

18. What is the disorder? Chromosome #7-salty skin in symptom
Lack enzyme to break down mucous in respiratory and digestive tract
Treatment with pounding chest
ANSWER: Cystic Fibrosis

19. What is this diagram called?
Pedigree
Punnett square
C.Kayrotype

20. What is this diagram called?
Punnett square
Pedigree
C.Kayrotype
ANSWER: C

21. What is this diagram called?
Punnett square
B. Pedigree
C. Karyotype

22. What is this diagram called?
Punnett square
B. Pedigree
C. Karyotype
ANSWER: B

23. What disorder is this?
TURNERS
KLINEFELTERS
DOWNS
METAFEMALE

24. What disorder is this? TURNERS KLINEFELTERS DOWNS METAFEMALE
ANSWER: XXY
Klinefelters

25. What disorder is this? A. TURNERS B. KLINEFELTERS C. METAFEMALE
D. DOWNS

26. What disorder is this? A. TURNERS B. KLINEFELTERS C. METAFEMALE
D. DOWNS
ANSWER: D

27. What are the chances of…
two Achrondroplasia parents having a normal sized child?
HINT: AA = dead
Aa = achondroplasia
aa = normal
ANSWER: 25%

28. What are the chances…
Of a father with hemophilia and a wife of no hemophilia gene having a child with hemophilia? Could any children be carriers?
ANSWER: 0% children; girls are carriers

29. What disorder is this? A. TURNERS B. KLINEFELTERS C. METAFEMALE
D. DOWNS
ANSWER: A

30. Which disorders ARE NOT caused by nondisjunction?
Klinefelters
Turners
Cystic Fibrosis
Trisomy 21
Hemophilia
ANSWERS:
Cystic Fibrosis
Hemophilia

31. What is the genotypic ratio of the offspring of parents AO and BO?

32. What is the genotypic ratio of the offspring of parents AO and BO?AB BO AO OO B O
What is the phenotypic ratio?

33. What is the genotypic ratio of the offspring of parents AO and BO?AB BO AO OO B O
What is the phenotypic ratio?
25% each blood types A, B, AB, O

34. What type of blood can each of these blood types RECEIVE?
AB+ B-
O+, A+
Only O+
Only O-
All +
O-, B-

36. In which phase of mitosis
Are the chromosomes stopped to make a karyotype?
A. prophase
B. telophase
C. metaphase
D. anaphase
ANSWER: METAPHASE

37. How are the chromosomes arranged
In a karyotype?
A. smallest to largest
B. largest to smallest
C. by color
D. by shape
ANSWER: B

38. Who is the oldest child in generation III?

39. Who is the oldest child in generation III?#1

40. If red hair is recessive and is shaded in, how many boys and how many girls have red hair?

41. If red hair is recessive and is shaded in, how many boys and how many girls have red hair?
2 boys + 2 girls

42. Is this person a male or female?

43. Is this person a male or female?

44. Is this person male or female?

45. Is this person male or female?
Normal
Or what
Disorder?

46. Is this person male or female?
Klinefelters

47. Is this a male or female?

48. Is this a male or female?
Female- Normal or a disorder?

49. Is this a male or female?
Female- TURNERS SYNDROME

50. This is a sex-linked trait
This is a sex-linked trait. Why is there no trait (shaded) in Generation II, but can be in III?

51. Just carriers in Generation II.

52. Which is NOT a sex-linked trait?
Klinefelters
Color-Blindness
Hemophilia
Duchenne Muscular Dystrophy
ANSWER: Klinefelters

53. Which is NOT genetic disorder?
Color Blindness
AIDS
Marfans
Tay Sachs
ANSWER:
AIDS

54. Make a Punnett Square for two parents AS for sickle-cell anemia.

55. Make a Punnett Square for two parents AS for sickle-cell anemia.

56. Make a Punnett Square for two parents AS for sickle-cell anemia.AA
(normal RBC) AS
(resistant to malaria) SS
(sickle-cell disease)
A S