1. Virus
What am I?

2. Virus
What am I?

3. Virus
What am I?

4. Virus
What am I?

5. Virus
What am I?

6. Virus
How do I spread?

7. Virus
How do I spread?

8. Virus
How do I spread?

9. Virus
How do I spread?

10. Virus
How do I spread?

11. What is my relationship between human behavior and me?
Virus
What is my relationship between human behavior and me?

12. What is my relationship between human behavior and me?
Virus
What is my relationship between human behavior and me?

13. What is my relationship between human behavior and me?
Virus
What is my relationship between human behavior and me?

14. What is my relationship between human behavior and me?
Virus
What is my relationship between human behavior and me?

15. What is my relationship between human behavior and me?
Virus
What is my relationship between human behavior and me?

16. What is my relationship between human behavior and me?
Virus
What is my relationship between human behavior and me?

17. What is my relationship between human behavior and me?
Virus
What is my relationship between human behavior and me?

18. What do you know about viruses?
Think
About the questions
Pair
Talk to your partner about the answers.
Share
Share with the class
What is a virus?
How do I spread?
What is my relationship between human behavior and me?
After starting the web presentation, allow one minute for thinking, talking and sharing.

19. Video Identify three new ideas about viruses
Show the video, either individually or on the TV/Projector
Have them identify three new ideas about viruses on post it notes.

21. What could this symbol mean?
What could the title mean?
Have the students read the table of contents
Have them find the list of characters and glossary at the back of the book.
Look at the map to determine the setting of the story.
Have them read the first seven pages and then call on a student to discuss the author’s purpose.

22. New Questions you need answered.
As you read, open to address below and add your questions to “Web Response” Or
Add your questions to post it notes.

23. QAR Strategy Right There: Think and Search: Author and you:
What is vomito Negro?
Think and Search:
What is the pattern of the virus’s effect on the body?
Author and you:
How does Monet’s experience in the emergency room relate to your own experiences in an emergency room or some other time when you needed swift attention?
On Your Own:
If you were seated next to a passenger with these symptoms, what would you do?
Student read the following chapters- IPAD 42-62, book 14-24
Students share at the their desks.

24. E.coli and T4 phage
After sharing have them put there stuff aside and prepare for the simulation.

25. Taking advantage of our social network
Virusbook
Taking advantage of our social network
Hand out the table for data,

26. Waiting for a flight

27. Procedures You must wear goggles at all times. Day 1:
Find a person from a different table.
Ask each other a question about the story.
Exchange 1 ml of water, if they did not know the answer, and ½ of ml of water if they did know the answer.
Find another person and ask another question.
Return to your desks and write down the names of the people you met.

28. Procedures You must wear goggles at all times. Day 2:
Find a person from a different table.
Ask each other a question about the story.
Exchange 1 ml of water, if they did not know the answer, and ½ of ml of water if they did know the answer.
Find another person and ask another question.
Return to your desks and write down the names of the people you met.

29. Infection

30. Did you contract the virus
One person in the Waiting room had the filovirus.
Who had it?
Did you have contact with that person?
Did you have contact with that person indirectly?
How can we be sure who has the virus?
Have them figure out who the carrier could be.
Discuss questions about the simulation and add questions to the poll.

31. Classify the questions
Right There
Think and Search
Author and You
On Your Own
Time to classify all the questions into the QAR

32. Search Pg 37-38; 62-67; 83-86; 98-100; 105-109; 117-118; 197-198
82-84; ; ; ; ; ;

33. Science @ Home Email me tonight your answers jorlinsky@dusd.net
1. What is a virus?
2. How do they spread?
3. How does human behavior affect the spread of viruses.
4. one question from the Classify QAR

34. Read 215-17 & 360-371 Read 350-354 & 567-584 Right There As you read…
What other ways can filovirus spread?
As you read…
Develop questions:
Think and Search
Author and you
On Your Own
Read &

35. EBOLA POSTER You will make a Ebola virus prevention poster.
It must include.
Very few words,
Pictures showing how to prevent the spread of the virus.
It should not scare people, but be informative.

37. Structure 20 nm Genomes Ds DNA (Papo, adeno, herpes, pox)
Ss DNA (Parvo)
Ds RNA (reovirus)
Ss+ RNA (pico and toga)
SS- RNA (Rhabdo,Paramyxo, Ortho)
Retrorivus ss RNA

38. Structure
Capsids
Protein coats
Phages

39. Structure
Some viruses have structures have membranous envelopes that help them infect hosts
These viral envelopes surround the capsids of influenza viruses and many other viruses found in animals
Viral envelopes, which are derived from the host cell’s membrane, contain a combination of viral and host cell molecules

40. Membranous envelope Capsid RNA Glycoprotein 80–200 nm (diameter) 50 nm
LE 18-4c
Membranous
envelope
Capsid
RNA
Glycoprotein
80–200 nm (diameter)
50 nm
Influenza viruses

41. Bacteriophages, also called phages, are viruses that infect bacteria
They have the most complex capsids found among viruses
Phages have an elongated capsid head that encloses their DNA
A protein tailpiece attaches the phage to the host and injects the phage DNA inside

42. Head DNA Tail sheath Tail fiber 80  225 nm 50 nm Bacteriophage T4
LE 18-4d
Head
DNA
Tail
sheath
Tail
fiber
80  225 nm
50 nm
Bacteriophage T4

43. LE 18-5
Entry into cell and
uncoating of DNA
VIRUS
DNA
Capsid
Replication
Transcription
HOST CELL
Viral DNA
mRNA
Viral DNA
Capsid
proteins
Self-assembly of
new virus particles
and their exit from cell

44. Reproduction

45. I. Double-stranded DNA (dsDNA) Adenovirus No Papovavirus
Class/Family
Envelope
Examples/Disease
I. Double-stranded DNA (dsDNA)
Adenovirus No
Respiratory diseases, animal tumors
Papovavirus
Papillomavirus (warts, cervical cancer): polyomavirus (animal tumors)
Herpesvirus
Yes
Herpes simplex I and II (cold sores, genital sores); varicella zoster (shingles, chicken pox); Epstein-Barr virus (mononucleosis, Burkitt’s lymphoma)
Poxvirus
Smallpox virus, cowpox virus
[NOTE TO PRODUCTION: PLEASE DO NOT include a jpeg of Table For better legibility, the table contents have been input as table text in slides 25, 26, 27, and 28.]

46. II. Single-stranded DNA (ssDNA) Parvovirus No
Class/Family
Envelope
Examples/Disease
II. Single-stranded DNA (ssDNA)
Parvovirus No
B19 parvovirus (mild rash)
III. Double-stranded RNA (dsRNA)
Reovirus
Rotavirus (diarrhea), Colorado tick fever virus
[NOTE TO PRODUCTION: PLEASE DO NOT include a jpeg of Table For better legibility, the table contents have been input as table text in slides 25, 26, 27, and 28.]

47. IV. Single-stranded RNA (ssRNA); serves as mRNA Picornavirus No
Class/Family
Envelope
Examples/Disease
IV. Single-stranded RNA (ssRNA); serves as mRNA
Picornavirus No
Rhinovirus (common cold); poliovirus, hepatitis A virus, and other enteric (intestinal) viruses
Coronavirus
Yes
Severe acute respiratory syndrome (SARS)
Flavivirus
Yellow fever virus, West Nile virus, hepatitis C virus
Togavirus
Rubella virus, equine encephalitis viruses
[NOTE TO PRODUCTION: PLEASE DO NOT include a jpeg of Table For better legibility, the table contents have been input as table text in slides 25, 26, 27, and 28.]

48. V. ssRNA; template for mRNA synthesis Filovirus Yes Orthomyxovirus
Class/Family
Envelope
Examples/Disease
V. ssRNA; template for mRNA synthesis
Filovirus
Yes
Ebola virus (hemorrhagic fever)
Orthomyxovirus
Influenza virus
Paramyxovirus
Measles virus; mumps virus
Rhabdovirus
Rabies virus
VI. ssRNA; template for DNA synthesis
Retrovirus
HIV (AIDS); RNA tumor viruses (leukemia)
[NOTE TO PRODUCTION: PLEASE DO NOT include a jpeg of Table For better legibility, the table contents have been input as table text in slides 25, 26, 27, and 28.]

49. Other Issues HIV and AIDS Viruses and Cancer Vaccines Plant Viruses
What’s New

50. Glycoprotein Viral envelope Capsid RNA (two identical strands) Reverse
transcriptase

51. The viral DNA that is integrated into the host genome is called a provirus
Unlike a prophage, a provirus remains a permanent resident of the host cell
The host’s RNA polymerase transcribes the proviral DNA into RNA molecules
The RNA molecules function both as mRNA for synthesis of viral proteins and as genomes for new virus particles released from the cell

52. LE 18-10 HOST CELL Reverse transcription Viral RNA RNA-DNA hybrid
Membrane of
white blood cell
HIV
HOST CELL
Reverse
transcription
Viral RNA
RNA-DNA
hybrid
0.25 µm
HIV entering a cell
DNA
NUCLEUS
Provirus
Chromosomal
DNA
RNA genome
for the
next viral
generation
mRNA
New HIV leaving a cell

53. Viral Diseases in Plants
More than 2,000 types of viral diseases of plants are known
Some symptoms are spots on leaves and fruits, stunted growth, and damaged flowers or roots

55. Plant viruses spread disease in two major modes:
Horizontal transmission, entering through damaged cell walls
Vertical transmission, inheriting the virus from a parent

56. Viroids and Prions: The Simplest Infectious Agents
Viroids are circular RNA molecules that infect plants and disrupt their growth
Prions are slow-acting, virtually indestructible infectious proteins that cause brain diseases in mammals
Prions propagate by converting normal proteins into the prion version
Normal prion protein are water soluble.
Prion’s not water soluble.
CJD and Mad cow Diseases

57. LE 18-13
Original
prion
Prion
Many prions
New
prion
Normal
protein

58. Evolution Evolution of viruses After first cells
Fragments of cellular nucleic acids
Similar genomes to hosts oncoviruses
Plasmids or Transposons
Selfreplicating genetic material in bacteria and fungi

59. What’s new? Prion’s can evolve: Scripps Research Institute in 2010…
Each time the protein replicates they’re minor changes and errors.
Any changes in the environment results in the best suited shapes multiplying faster.

60. What’s new? Prion’s found in Yeast and are a part of epigenetics
MIT 2011
Yeast prions affect RNA transcription that causes changes in the protein.
Found in 255 of the 700 different species of yeast.
May only be a yeast issue.

61. What’s new with viruses
8% of our DNA sequence has viral genomes
2000
Syncytin a viral protein part of the evolution of placental mammals.
This protein fuses cells together; required in development of the placenta and fetus

62. The Story of Syncytin grows
Chimps gorillas and primates all have the same protein.
found syncytin 1 and 2 part of pre-eclampsia
Dangerous high blood pressure if synctin 1 or 2 not working.
Syncytin 2 slow’s mother’s immunes system down so it does not attack the fetus.
2005 found syncytin in mice, and it is required for survival of the fetus.
Mouse and primate syncytin different sequences, different virus.

63. The Story of Syncytin grows
Rabbits have an additional different syncytin sequence.
This sequence not in their closely related cousins: the Pika.
Conclusion: new Syncytin infected rabbits 30mya.

64. The Story of Syncytin grows
Syncytin in
Carnivores