1. Fungal Infections, Pathogenesis and Treatment

2. Fungal infections 400 out of 75,000 Primary infections
Opportunistic infections
Myco-toxins
Allergy

3. Mycoses
Superficial and cutaneous
Subcutaneous
Deep (systemic)

4. Examples of yeast of medical importance
Candida species
Cryptococcus neoformans
Malassezia species

5. Examples of moulds of medical importance
Dermatophytes
Aspergillus species
Zygomycetes

6. Superficial and Cutaneous Mycoses
Skin, hair, nail and mucus membranes
Most common
World-wide
Ringworm infections du to Dermatophytes
Yeast infections due to Candida

7. pityriasis versicolor

8. pityriasis versicolor
Direct examination
pityriasis versicolor
Filaments are not seen at unaffected skin sites or in culture

9. Tinea nigra

10. Skin scrapings
Tinea nigra

11. Intertrigo caused by Canddia albicans

12. Dermatophytosis
Dermatophytosis caused by M. canis following contact with infectious cat

13. Dermatophytosis direct skin examination

14. Dermatophytosis

15. Fungal nail infection

16. Subcutaneous Mycoses Skin, subcutaneous tissues, fascia and bone
Localized
Trauma
More in tropics
Mycetoma, chromomycosis and sporotrichosis

17. Mycetoma

18. Mycetoma

19. Sporotrichosis A 60-year-old woman developed multiple subcutaneous
nodules and abscesses on her right hand and forearm
7 days after finger thorn prick

20. Chromoblastomycosis: Fonsecaea pedrosoi
Classical
Chromoblastomycosis:
Fonsecaea pedrosoi
De Hoog, Centraalbureau voor Schimmelcultures

21. Nodulose chromoblastomycosis (Senegal): Fonsecaea pedrosoi
De Hoog, Centraalbureau voor Schimmelcultures

22. Systemic Mycoses Deep-seated Inhalation Primary (restricted)
Opportunistic (world-wide)

23. Opportunistic fungal infections
Aspergillosis
Pulmonary
Disseminated
Para nasal sinusitis
Candidiasis
Candidemia
Cryptococcus meningitis

24. Polyene antifungal agents
Amphotericin B
Nystatin

25. Azoles antifungal agents
Clotrimazole
Econazole
Ketoconazole
Miconazole
Fluconazole
Itraconazole
Posaconazole
Voriconazole

26. Other antifungal agents
Echinocandins
Anidulafungin
Caspofungin
Micafungin
Terbinafine
5-fluorocytosine